Biodistribution of 4 Amino Acid Analogs and 18F-FDG in Wag/Rij Rats
| Tissue | Mean ± SD differential absorption ratio for: | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 125I-3-IMT | 125I-2-IT | 125I-2-IPhe | 125I-4-IPhe | 18F-FDG | |||||
| Blood | 1.08 ± 0.41 | 1.36 ± 0.13 | 1.36 ± 0.39 | 2.38 ± 0.22 | 0.68 ± 0.17 | ||||
| Heart | 1.05 ± 0.29 | 1.32 ± 0.06 | 1.28 ± 0.13 | 1.56 ± 0.13 | 5.54 ± 2.48 | ||||
| Lung | 1.13 ± 0.46 | 1.30 ± 0.19 | 1.40 ± 0.22 | 1.38 ± 0.94 | 1.17 ± 0.27 | ||||
| Liver | 1.73 ± 0.45 | 1.63 ± 0.06 | 1.37 ± 0.26 | 1.68 ± 0.21 | 0.70 ± 0.06 | ||||
| Spleen | 0.87 ± 0.18 | 1.44 ± 0.01 | 1.39 ± 0.40 | 1.73 ± 0.19 | 1.67 ± 0.23 | ||||
| Pancreas | 3.35 ± 0.69 | 5.31 ± 0.55 | 3.80 ± 0.17 | 5.84 ± 0.09 | 0.43 ± 0.06 | ||||
| Stomach | 1.84 ± 0.14 | 1.37 ± 0.16 | 1.20 ± 0.03 | 1.32 ± 0.48 | 0.83 ± 0.16 | ||||
| Small intestine | 0.85 ± 0.19 | 1.40 ± 0.07 | 1.14 ± 0.14 | 1.24 ± 0.08 | 1.26 ± 0.20 | ||||
| Large intestine | 1.02 ± 0.64 | 1.34 ± 0.25 | 0.88 ± 0.13 | 0.95 ± 0.02 | 1.44 ± 0.42 | ||||
| Bone | 0.29 ± 0.13 | 0.51 ± 0.24 | 0.42 ± 0.04 | 0.43 ± 0.37 | 0.93 ± 0.36 | ||||
| Brain | 0.80 ± 0.08 | 1.11 ± 0.09 | 0.84 ± 0.08 | 1.04 ± 0.08 | 3.30 ± 0.16 | ||||
| Kidney (right) | 16.22 ± 3.58 | 3.35 ± 0.16 | 1.99 ± 0.29 | 1.64 ± 0.10 | 1.53 ± 0.15 | ||||
| Kidney (left) | 18.31 ± 1.66 | 3.51 ± 0.24 | 2.03 ± 0.16 | 1.61 ± 0.16 | 1.51 ± 0.15 | ||||
| Muscle (noninflamed) | 0.40 ± 0.08 | 1.16 ± 0.23 | 0.98 ± 0.03 | 1.09 ± 0.04 | 0.29 ± 0.24 | ||||
| Muscle (inflamed) | 0.71 ± 0.14 | 1.25 ± 0.04 | 1.11 ± 0.16 | 1.50 ± 0.08 | 0.83 ± 0.16 | ||||
n = 3 for amino acid tracers and n = 12 for 18F-FDG.