TABLE 2

Normal Tissue Accumulation of 111In-DTPA-hEGF 24 Hours After Subcutaneous or Intravenous Injection in Non-Tumor-Bearing Athymic Mice

TissueNormal tissue accumulation (%ID/g) after injection by*:
Intravenous routeSubcutaneous route
Blood0.27 ± 0.05†0.17 ± 0.04†
Heart0.82 ± 0.150.51 ± 0.06
Lungs1.23 ± 0.111.06 ± 0.24
Liver18.30 ± 4.34‡12.49 ± 4.08‡
Stomach1.09 ± 0.091.15 ± 0.27
Intestines2.96 ± 0.671.98 ± 0.29
Spleen5.09 ± 1.012.44 ± 0.78
Kidneys22.46 ± 4.01§18.26 ± 3.84§

  • ↵* Mean ± SEM for 4–6 animals per group.

  • ↵† Not significantly different (t test; P = 0.141).

  • ↵‡ Not significantly different (t test; P = 0.362).

  • ↵§ Not significantly different (t test, P = 0.474).