TABLE 1

Physiologic Parameters After mCPP Treatments in Conscious Rhesus Monkeys

ParameterBeforeTime after mCPP treatment (min)
20 min40 min70 min100 min
0.2 mg/kg
 MABP (mm Hg)161 ± 4164 ± 7154 ± 5142 ± 15148 ± 7
 HR (beats/min)204 ± 13192 ± 17197 ± 19198 ± 20199 ± 16
 pH7.468 ± 0.0307.433 ± 0.0387.420 ± 0.0427.445 ± 0.0207.449 ± 0.007
 pO2 (mm Hg)99.8 ± 3.691.3 ± 3.791.3 ± 3.686.0 ± 4.085.9 ± 4.4
 pCO2 (mm Hg)31.6 ± 1.734.2 ± 2.034.6 ± 1.934.9 ± 1.835.7 ± 1.7
 Glucose (mg/dL)133.2 ± 22.9119.8 ± 14.3106.0 ± 11.494.2 ± 13.090.4 ± 12.9
1.0 mg/kg
 MABP (mm Hg)150 ± 7149 ± 6147 ± 6148 ± 8146 ± 7
 HR (beats/min)191 ± 5180 ± 14180 ± 8177 ± 6181 ± 3
 pH7.487 ± 0.0097.405 ± 0.0177.451 ± 0.0067.451 ± 0.0057.446 ± 0.004
 pO2 (mm Hg)99.7 ± 4.893.2 ± 0.992.3 ± 1.7100.6 ± 2.798.5 ± 2.3
 pCO2 (mm Hg)32.2 ± 3.037.5 ± 1.536.2 ± 2.735.5 ± 0.936.8 ± 0.8
 Glucose (mg/dL)110.0 ± 27.092.2 ± 9.499.0 ± 21.084.8 ± 6.090.8 ± 4.6
5.0 mg/kg
 MABP (mm Hg)156 ± 7157 ± 6147 ± 8146 ± 8145 ± 7
 HR (beats/min)196 ± 10181 ± 13178 ± 12179 ± 12192 ± 9
 pH7.471 ± 0.0177.459 ± 0.0307.464 ± 0.0097.437 ± 0.0067.424 ± 0.007
 pO2 (mm Hg)98.4 ± 4.893.1 ± 2.699.6 ± 2.7108.7 ± 4.9106.4 ± 4.8
 pCO2 (mm Hg)33.0 ± 3.340.6 ± 4.340.8 ± 4.637.2 ± 3.139.8 ± 3.1
 Glucose (mg/dL)101.5 ± 24.890.0 ± 10.891.0 ± 16.294.0 ± 13.0103.5 ± 12.9
  • MABP and HR = mean arterial blood pressure and heart rate, respectively.

  • Data represent mean ± SD (n = 5).