Percentage Differences in Organ AUC Between Baseline and Modulator (XR9576) Studies
| Organ (n = 3) | Mean baseline AUC | Mean modulator AUC | % change | P | ||||
|---|---|---|---|---|---|---|---|---|
| Organ AUC normalized to metabolite-corrected plasma AUC* | ||||||||
| Spleen | 2.8 ± 0.3 | 2.7 ± 0.5 | −3 | 0.64 | ||||
| Kidney | 4.9 ± 0.7 | 4.3 ± 0.6 | −12 | 0.023 | ||||
| Muscle | 0.6 ± 0.3 | 0.7 ± 0.3 | 15 | 0.07 | ||||
| Vertebrae | 1.1 ± 0.3 | 1.1 ± 0.2 | 4 | 0.42 | ||||
| Lung | 0.2 ± 0.1 | 0.4 ± 0.1 | 97 | 0.04 | ||||
| Liver | 24.2 ± 5.6 | 37.3 ± 12.3 | 54 | 0.077 | ||||
| Brain | 0.05 ± 0.01 | 0.06 ± 0.02 | 20 | 0.33 | ||||
| Organ AUC normalized to ID/animal weight* | ||||||||
| Spleen | 59.4 ± 7.8 | 54.1 ± 1.8 | −9 | 0.26 | ||||
| Kidney | 101 ± 18 | 86.2 ± 12.7 | −15 | 0.054 | ||||
| Muscle | 11.7 ± 3.0 | 13.2 ± 2.1 | 13 | 0.17 | ||||
| Vertebrae | 21.8 ± 3.1 | 22.3 ± 1.9 | 2 | 0.72 | ||||
| Lung | 3.8 ± 0.6 | 7.4 ± 0.6 | 93 | 0.04 | ||||
| Liver | 489 ± 63 | 720 ± 134 | 47 | 0.030 | ||||
| Brain | 1.0 ± 0.2 | 1.1 ± 0.1 | 15 | 0.37 | ||||
| Plasma† | 20.8 ± 3.2 | 21.0 ± 3.1 | 1 | 0.69 | ||||