Percentage Difference in Logan Plot Slope Values Between Baseline and Modulator (XR9576) Studies
| Organ | Mean baseline | Mean modulator | % change | P |
|---|---|---|---|---|
| Spleen | 13.8 ± 3.8 | 13.4 ± 2.5 | −3 | 0.81 |
| Kidney | 25.3 ± 6.1 | 21.8 ± 6.7 | −14 | 0.08 |
| Muscle | 6.5 ± 0.2 | 7.2 ± 1.0 | 11 | 0.38 |
| Vertebrae | 6.4 ± 1.5 | 6.5 ± 1.7 | 3 | 0.87 |
| Lung | 1.1 ± 0.1 | 2.0 ± 0.5 | 87 | 0.11 |
| Liver | 160 ± 9 | 327 ± 31 | 104 | 0.02 |
Logan plot slope (mL plasma/mL tissue) provides estimate of tracer Vd for organ. Increase in tracer retention would produce increased Vd. Mean values ± SD are averages over 3 monkeys.