Percentage Change Between Paired Baseline Studies
| Organ | Logan plot slope (Vd) | ID/weight-normalized AUC* | Plasma-normalized AUC† |
|---|---|---|---|
| Spleen | 3 | −27 | −12 |
| Kidney | 6 | −18 | −5 |
| Muscle | −6 | −6 | 2 |
| Vertebrae | 1 | −18 | 5 |
| Lung | 15 | −28 | 2 |
| Liver | −5 | −5 | 20 |
| Brain | 15 | 25 |
↵* Organ area under time–activity curve (AUC) normalized to ID/animal weight.
↵† Organ AUC normalized to area under metabolite-corrected plasma time–activity curve.
Percentage difference of mean (averaged over 3 monkeys) first and mean second baseline studies is shown. Logan plot slope for brain could not be accurately calculated due to low organ activity.