Tissue Distribution of [111ln-DTPA-d-Phe1]Octreotide in Wild-Type and sst2 Knockout Mice
| Tissue | Wild type | sst2 knockout | ||||
|---|---|---|---|---|---|---|
| Without blockade | With blockade | Without blockade | With blockade | |||
| Pituitary gland | 1.2 ± 0.2 | 0.25 ± 0.04* | 0.033 ± 0.037† | 0.19 ± 0.03 | ||
| Adrenals | 0.26 ± 0.03 | 0.12 ± 0.04* | 0.045 ± 0.020† | 0.11 ± 0.03‡ | ||
| Thymus | 0.30 ± 0.05 | 0.061 ± 0.020* | 0.017 ± 0.003† | 0.039 ± 0.010* | ||
| Pancreas | 0.18 ± 0.03 | 0.035 ± 0.008* | 0.007 ± 0.002† | 0.014 ± 0.005 | ||
| Spleen | 0.048 ± 0.008 | 0.074 ± 0.021 | 0.075 ± 0.006 | 0.072 ± 0.016 | ||
| Liver | 0.090 ± 0.007 | 0.19 ± 0.05‡ | 0.11 ± 0.01 | 0.15 ± 0.03 | ||
| Kidneys | 1.4 ± 0.3 | 1.9 ± 0.4 | 2.4 ± 0.5 | 2.3 ± 1.1 | ||
| Soft tissue | 0.004 ± 0.001 | 0.010 ± 0.006 | 0.003 ± 0.000 | 0.009 ± 0.002 | ||
| Blood | 0.004 ± 0.001 | 0.10 ± 0.00 | 0.005 ± 0.001 | 0.011 ± 0.004‡ | ||
↵* P < 0.01 for [111ln-DTPA-d-Phe1]octreotide vs. [111ln-DTPA-d-Phe1]octreotide with blockade.
↵† P < 0.01 for [111ln-DTPA-d-Phe1]octreotide wild type vs. [111ln-DTPA-d-Phe1]octreotide sst2 knockout.
↵‡ P < 0.05 for [111ln-DTPA-d-Phe1]octreotide vs. [111ln-DTPA-d-Phe1]octreotide with blockade.
Values are mean ± SD percentage injected dose per gram of tissue (n = 4 animals per group). Blockade means coinjection of 100 μg octreotide with [111ln-DTPA-d-Phe1]octreotide.