TABLE 2

Biodistribution (%ID/g ± SD) of 2.0 μg of Nonpretargeted ⁶⁴Cu-DOTA-Biotin in Athymic Nude Mice Bearing SW1222 Human Colorectal Carcinoma Xenografts

Tissue	5 min	30 min	1 h	2 h	4 h	24 h	48 h
Blood	7.43 ± 1.43	1.14 ± 0.21	0.52 ± 0.12	0.24 ± 0.08	0.29 ± 0.04	0.17 ± 0.03	0.17 ± 0.08
Liver	4.16 ± 0.88	4.52 ± 1.39	4.76 ± 0.81	3.74 ± 0.76	4.50 ± 0.81	1.85 ± 0.37	1.27 ± 0.30
Spleen	1.70 ± 0.25	0.50 ± 0.07	0.56 ± 0.17	0.41 ± 0.10	0.46 ± 0.10	0.25 ± 0.05	0.24 ± 0.08
Kidney	19.8 ± 3.93	3.64 ± 0.32	2.92 ± 0.59	2.10 ± 0.59	1.79 ± 0.32	1.05 ± 0.17	0.81 ± 0.12
Muscle	2.66 ± 0.39	0.66 ± 0.18	0.39 ± 0.20	0.14 ± 0.05	0.16 ± 0.03	0.09 ± 0.02	0.09 ± 0.03
Bone	2.42 ± 0.74	0.45 ± 0.05	0.44 ± 0.12	0.34 ± 0.27	0.51 ± 0.23	0.18 ± 0.05	0.10 ± 0.04
Uterus	4.22 ± 1.16	1.25 ± 0.30	0.94 ± 0.43	0.82 ± 0.26	0.78 ± 0.28	0.50 ± 0.23	0.10 ± 0.08
Ovaries	3.51 ± 0.73	0.84 ± 0.43	0.71 ± 0.29	0.32 ± 0.08	0.39 ± 0.06	0.22 ± 0.09	0.14 ± 0.07
Stomach	1.39 ± 0.26	1.28 ± 0.83	2.08 ± 0.96	0.92 ± 0.31	0.54 ± 0.08	0.81 ± 0.67	0.36 ± 0.06
Small intestine	2.26 ± 0.66	2.16 ± 0.55	4.21 ± 1.59	1.24 ± 0.34	1.54 ± 0.30	0.64 ± 0.16	0.42 ± 0.08
Upper large intestine	2.89 ± 1.51	1.72 ± 0.45	2.79 ± 1.38	2.10 ± 0.37	2.19 ± 0.32	1.04 ± 0.40	0.51 ± 0.12
Lower large intestine	2.06 ± 0.90	0.70 ± 0.15	0.81 ± 0.26	1.95 ± 0.07	3.35 ± 0.72	2.25 ± 0.37	0.87 ± 0.18
Tumor	2.34 ± 0.37	0.85 ± 0.20	0.75 ± 0.14	0.59 ± 0.13	0.63 ± 0.10	0.56 ± 0.07	0.53 ± 0.09