Results of Invasive Measurements and PET Measurements
| Study type | No. of studies* | COthermo (L/min) | HR (min−1) | PCWP (mm Hg) | SVnorm (% of baseline) | RV-COPET (L/min) | LV-COPET (L/min) | Lung-uptake (%ID) | Normalized lung-uptake (% of baseline) |
|---|---|---|---|---|---|---|---|---|---|
| Base 1 | 5 (4) | 4.0 ± 0.2 | 98 ± 7 | 7 ± 1 | 100 | 4.4 ± 0.5 | 4.2 ± 0.4 | 3.8 ± 0.7 | 100 |
| Base 2 | 4 (3) | 3.6 ± 0.6 | 95 ± 11 | 7 ± 1 | 95 ± 11 | 4.4 ± 0.8 | 3.8 ± 0.4 | 3.7 ± 0.7 | 106 ± 15 |
| Dobut | 6 (5) | 6.6 ± 1.4 | 130 ± 11 | 7 ± 1 | 123 ± 18 | 6.9 ± 1.0 | 6.4 ± 1.3 | 3.6 ± 0.3 | 93 ± 12 |
| Metop | 6 (5) | 3.0 ± 1.0 | 85 ± 17 | 9 ± 1 | 81 ± 13 | 3.2 ± 1.0 | 3.1 ± 0.9 | 5.7 ± 1.9 | 141 ± 34 |
| Angioten | 3 | 4.0 ± 0.2 | 105 ± 14 | 13 ± 1 | 90 ± 2 | 4.0 ± 0.6 | 3.6 ± 0.2 | 4.3 ± 0.7 | 126 ± 10 |
↵* Numbers in parentheses refer to PCWP.
COthermo = estimates of CO based on invasive thermodilution; SVnorm = stroke volume, normalized to baseline study in each animal; RV-COPET and LV-COPET = noninvasive CO estimates derived from PET-based analysis of first-pass activities in RV and LV ROI, respectively; Base 1 = baseline study; Base 2 = repeated baseline study; Dobut = infusion of dobutamine (20–25 μg/kg/min); Metop = combined high-dose injection of β-blocking agent metoprolol and morphine; Angioten = infusion of angiotensinamide (2.5 mg/kg/min).