TABLE 2

Biodistribution of 111In-CHX-A″-DTPA CLB-CD19 and Control Antibody in ALL-Engrafted SCID Mice

Organ%ID/g*
0.25 h†4 h†24 h†48 h†72 h†120 h†Control‡ 24 h
Blood1.51 ± 0.177.31 ± 4.033.46 ± 1.141.58 ± 0.351.41 ± 0.485.55 ± 3.8021.59 ± 3.11
Liver20.46 ± 7.3521.76 ± 7.4122.10 ± 11.048.80 ± 0.3412.66 ± 3.738.14 ± 1.2115.32 ± 1.48
Spleen8.89 ± 3.5443.69 ± 35.6072.78 ± 13.6742.45 ± 11.3331.91 ± 3.727.58 ± 3.499.37 ± 1.59
Kidney3.41 ± 1.265.04 ± 2.547.97 ± 1.867.01 ± 1.663.96 ± 0.684.40 ± 1.467.59 ± 0.58
Bone1.65 ± 0.963.44 ± 2.879.41 ± 3.566.75 ± 3.185.62 ± 4.265.37 ± 3.212.65 ± 0.22
Lung8.67 ± 1.0510.95 ± 3.485.44 ± 0.733.97 ± 0.652.50 ± 0.556.45 ± 3.5112.23 ± 1.26
Stomach2.48 ± 1.812.16 ± 0.911.54 ± 0.380.90 ± 0.100.65 ± 0.080.99 ± 0.622.36 ± 0.95

  • ↵* Values are expressed as mean ± SD, where n = 5 (except at 120 h, where n = 3 or 4).

  • ↵† Time after injection of radioconjugate.

  • ↵‡ Control consists of 111In-CHX-A″-DTPA HRS-3 at 24 h after injection.