TABLE 1

Hemodynamic Parameters: Isolated Rat Heart Experiments

	Time after ^99mTcN-NOET injection (min)
		Baseline	0	15	30	45	60
LVESP (mm Hg)
Control (no BSA)	100.0 ± 4.6	103.1 ± 4.2	104.3 ± 4.8	102.1 ± 5.0	96.0 ± 3.3	97.6 ± 3.2
FA-free BSA	99.3 ± 7.4	93.5 ± 3.4	94.8 ± 4.0	98.2 ± 2.3	91.9 ± 1.4	94.8 ± 3.3
BSA	107.9 ± 5.8	104.5 ± 6.2	107.0 ± 6.6	99.1 ± 6.1	99.0 ± 4.2	100.2 ± 3.9
LVEDP (mm Hg)
Control (no BSA)	4.5 ± 0.2	4.3 ± 0.3	3.5 ± 0.3	4.0 ± 0.3	3.2 ± 0.3	3.1 ± 0.3
FA-free BSA	3.8 ± 0.2	4.0 ± 0.4	4.8 ± 0.6	5.2 ± 0.5	5.2 ± 0.2*	5.0 ± 0.5^†
BSA	5.3 ± 0.3	4.3 ± 0.2	4.5 ± 0.2	4.2 ± 0.4	4.3 ± 0.5	5.0 ± 0.5^†
CPP (mm Hg)
Control (no BSA)	35.0 ± 1.9	33.6 ± 1.4	35.2 ± 1.6	36.3 ± 2.1	35.3 ± 1.8	37.3 ± 1.6
FA-free BSA	32.4 ± 2.0	33.2 ± 2.7	33.3 ± 1.8	35.1 ± 1.9	35.9 ± 1.6	36.3 ± 1.7
BSA	37.2 ± 2.4	34.5 ± 2.6	37.2 ± 2.5	36.0 ± 2.5	36.3 ± 1.7	38.0 ± 2.0
dP/dt_max (mm Hg/s)
Control (no BSA)	4,507 ± 403	4,506 ± 462	4,480 ± 402	4,660 ± 352	4,484 ± 205	4,676 ± 483
FA-free BSA	4,209 ± 384	3,667 ± 560	3,612 ± 214	4,164 ± 367	4,207 ± 101	3,882 ± 236
BSA	4,547 ± 557	4,526 ± 303	4,900 ± 538	4,542 ± 334	4,567 ± 604	4,288 ± 348

↵* P < 0.05 vs. baseline.
↵^† P < 0.05 vs. control (no BSA).
LVESP = left ventricular end-systolic pressure; LVEDP = left ventricular end-diastolic pressure; CPP = coronary perfusion pressure; dP/dt = peak positive first derivative of left ventricular pressure with respect to time.