Biodistribution in Mice After Intravenous Injection of 11C-αMDG, 11C-βMDG, and 11C-Methyl-l-Glucoside (Mixture of Isomers)
| Biodistribution | 11C-αMDG, 30 min after injection | 11C-βMDG, 30 min after injection | 11C-Methyl-l-glucoside,* 30 min after injection | ||||||
|---|---|---|---|---|---|---|---|---|---|
| %ID | %ID/g | %ID | %ID/g | %ID | %ID/g | ||||
| Urine | 0.88 ± 0.56 | 2.26 ± 0.09 | 42.70 ± 1.51 | ||||||
| Kidneys | 8.46 ± 1.00 | 11.25 ± 1.72 | 31.28 ± 8.06 | 35.16 ± 11.95 | 7.09 ± 3.00 | 8.94 ± 2.11 | |||
| Liver | 11.31 ± 1.24 | 4.93 ± 0.06 | 8.38 ± 0.64 | 3.90 ± 0.88 | 8.12 ± 0.90 | 4.40 ± 0.59 | |||
| Spleen | 0.70 ± 0.46 | 2.18 ± 1.41 | 0.55 ± 0.07 | 1.91 ± 0.73 | 0.70 ± 0.10 | 2.28 ± 0.50 | |||
| Lungs | 1.75 ± 0.24 | 5.27 ± 0.32 | 1.07 ± 0.17 | 3.89 ± 1.27 | 0.87 ± 0.19 | 3.43 ± 0.68 | |||
| Heart | 0.49 ± 0.12 | 3.24 ± 0.86 | 0.44 ± 0.04 | 1.82 ± 0.73 | 0.39 ± 0.12 | 2.15 ± 0.56 | |||
| Intestines | 7.47 ± 0.31 | 1.96 ± 0.38 | 5.90 ± 0.75 | 1.31 ± 0.37 | 5.13 ± 0.37 | 1.58 ± 0.18 | |||
| Stomach | 1.31 ± 0.48 | 1.92 ± 0.59 | 0.50 ± 0.70 | 0.79 ± 0.77 | 0.54 ± 0.47 | 1.13 ± 0.88 | |||
| Blood | 19.22 ± 1.81 | 6.78 ± 0.32 | 12.45 ± 2.41 | 4.51 ± 1.39 | 6.68 ± 1.14 | 2.68 ± 0.57 | |||
| Carcass | 59.43 ± 2.53 | 1.94 ± 0.10 | 42.76 ± 6.25 | 1.49 ± 0.25 | 31.25 ± 3.75 | 1.08 ± 0.14 | |||
↵* Mixture of α- and β-anomers.
%ID = percentage of injected dose.
Values are mean ± SD (n = 4).