Biodistribution in Normal Mice and Mice Pretreated with Phlorizin (800 mg/kg) After Intravenous Injection of 11C-Methyl-d-Glucoside (Mixture of Anomers)
| Biodistribution | 10 min after injection | 30 min after injection | 30 min after injection (pretreatment with phlorizin) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| %ID | %ID/g | %ID | %ID/g | %ID | %ID/g | ||||
| Urine | 1.13 ± 0.54 | 2.35 ± 0.69 | 9.11 ± 13.03 | ||||||
| Kidneys | 21.23 ± 3.83 | 22.21 ± 6.05 | 25.97 ± 4.74 | 29.82 ± 2.14 | 5.76 ± 1.83 | 10.10 ± 2.67 | |||
| Liver | 10.40 ± 0.82 | 4.59 ± 0.85 | 10.08 ± 1.44 | 4.26 ± 0.48 | 9.77 ± 1.35 | 5.17 ± 0.42 | |||
| Spleen | 0.45 ± 0.27 | 1.86 ± 0.14 | 0.30 ± 0.15 | 2.38 ± 0.20 | 0.41 ± 0.09 | 2.84 ± 0.38 | |||
| Lungs | 1.71 ± 0.36 | 4.77 ± 0.66 | 1.27 ± 0.05 | 4.62 ± 0.33 | 1.48 ± 0.67 | 5.40 ± 1.14 | |||
| Heart | 0.45 ± 0.05 | 2.05 ± 0.25 | 0.56 ± 0.07 | 2.32 ± 0.25 | 0.48 ± 0.05 | 3.07 ± 0.57 | |||
| Intestines | 5.85 ± 0.44 | 1.36 ± 0.24 | 5.51 ± 0.61 | 1.44 ± 0.10 | 8.54 ± 1.77 | 2.33 ± 0.46 | |||
| Stomach | 0.66 ± 0.07 | 0.86 ± 0.32 | 1.21 ± 0.47 | 1.47 ± 0.49 | 1.12 ± 0.33 | 2.13 ± 0.54 | |||
| Cerebrum | 0.09 ± 0.01 | 0.27 ± 0.03 | 0.08 ± 0.02 | 0.25 ± 0.04 | 0.19 ± 0.04 | 0.63 ± 0.15 | |||
| Cerebellum | 0.04 ± 0.02 | 0.36 ± 0.06 | 0.04 ± 0.02 | 0.35 ± 0.06 | 0.09 ± 0.04 | 0.93 ± 0.22 | |||
| Blood | 17.73 ± 1.44 | 5.32 ± 0.67 | 17.24 ± 0.94 | 5.11 ± 0.22 | 14.31 ± 2.87 | 6.21 ± 1.27 | |||
| Carcass | 50.04 ± 4.14 | 1.37 ± 0.17 | 45.62 ± 4.54 | 1.21 ± 0.15 | 54.08 ± 10.69 | 2.19 ± 0.42 | |||
%ID = percentage of injected dose.
Values are mean ± SD (n = 4).