Summary of Patient Population Clinical Characteristics
| Patient no. | Sex | Age (y) | Reincke* (NF, SC-CS, PC-CS) | Morning ACTH (ng/L) | Morning cortisol (nmol/L) | UFC (nmol/24 h) | Adenoma diameter (cm) | Hypertension | NIDDM | BMI |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 57 | NF | 25 | 310 | 105 | 1.5 | − | − | <25 |
| 2 | F | 49 | NF | 33.4 | 349 | 115 | 1.5 | − | − | <25 |
| 3 | M | 69 | NF | 31 | 315 | 200 | 1.5 | − | − | <25 |
| 4 | M | 58 | NF | 22 | 430 | 190 | 2.0 | − | − | <25 |
| 5 | M | 54 | NF | 25.5 | 336 | 104 | 2.0 | − | − | <25 |
| 6 | F | 56 | NF | 16 | 325 | 184 | 1.7 | − | − | <25 |
| 7 | F | 75 | NF | 32.3 | 250 | 228 | 2.5 | − | − | <25 |
| 8 | F | 61 | NF | 25 | 300 | 180 | 1.5 | − | − | <25 |
| 9 | M | 53 | NF | 33 | 588 | 200 | 3.5 | − | − | <25 |
| 10 | M | 55 | NF | 19.6 | 578 | 70 | 1.5 | − | − | <25 |
| 11 | F | 51 | NF | 25 | 250 | 170 | 1.5 | − | − | <25 |
| 12 | F | 71 | NF | 14 | 362 | 192 | 1.5 | − | − | <25 |
| 13 | M | 51 | NF | 18.3 | 512 | 244 | 3 | − | − | <25 |
| 14 | M | 41 | NF | 22.1 | 429 | 639 | 1.6 | − | − | <25 |
| 15 | M | 22 | NF | 22.7 | 448 | 222 | 2.2 | − | − | <25 |
| 16 | F | 70 | NF | 23 | 450 | 200 | 2 | − | − | <25 |
| 17 | F | 66 | SC | 9 | 552 | 110 | 2.5 | − | − | <25 |
| 18 | F | 65 | SC | 9 | 320 | 215 | 1.5 | − | − | <25 |
| 19 | F | 45 | SC | 9 | 330 | 107 | 2.5 | − | − | <25 |
| 20 | M | 57 | SC | 9 | 497 | 144 | 3 | − | − | <25 |
| 21 | M | 62 | SC | 9 | 412 | 113 | 3 | − | − | <25 |
| 22 | M | 57 | SC | 10 | 424 | 465 | 1.5 | − | − | <25 |
| 23 | M | 61 | SC | 10.3 | 429 | 188 | 3 | − | − | <25 |
| 24 | M | 52 | SC | 7.8 | 406 | 207 | 2.5 | − | − | <25 |
| 25 | M | 62 | SC | 5 | 420 | 460 | 2.5 | − | − | <25 |
| 26 | F | 38 | PC | 9 | 825 | 3,280 | 3 | Moderate | + | <25 |
| 27 | M | 73 | PC | 9 | 450 | 1,173 | 4 | Moderate | − | 28 |
| 28 | M | 62 | PC | 5 | 419 | 637 | 2 | Moderate | + | <25 |
| 29 | F | 60 | PC | 10 | 610 | 296 | 4 | Moderate | + | <25 |
| 30 | F | 55 | PC | 10 | 277 | 124 | 4 | Moderate | + | 30 |
| 31 | F | 63 | PC | 5.2 | 485 | 236 | 3.8 | Moderate | − | 34 |
| 32 | F | 62 | PC | 7 | 459 | 86 | 2.1 | Moderate | − | 27 |
| 33 | M | 61 | PC | 10.8 | 424 | 155 | 3 | Moderate | − | 29 |
| 34 | M | 61 | PC | 9 | 753 | 460 | 2 | Moderate | + | <25 |
| 35 | M | 49 | PC | 9 | 526 | 194 | 3.5 | Moderate | − | 28 |
| 36 | F | 56 | PC | 9 | 586 | 158 | 2 | Moderate | − | 35 |
| 37 | F | 58 | PC | 10.5 | 671 | 444 | 5.8 | Moderate | + | <25 |
| 38 | F | 52 | PC | 6.3 | 977 | 230 | 3.5 | Moderate | + | <25 |
| 39 | M | 53 | PC | 9 | 361 | 174 | 4 | Moderate | − | 28 |
| 40 | M | 75 | PC | 9 | 342 | 143 | 2 | Moderate | − | 29 |
| 41 | F | 60 | PC | 8.1 | 391 | 150 | 2.7 | Moderate | − | 28 |
| 42 | F | 37 | PC | 9 | 570 | 480 | 3 | Moderate | − | 27 |
| 43 | M | 58 | PC | 4.5 | 107 | 145 | 3.5 | Moderate | + | <25 |
| 44 | M | 46 | PC | 9 | 494 | 234 | 4.5 | Moderate | − | 34 |
| 45 | F | 68 | PC | 9.6 | 240 | 182 | 3.2 | − | + | 31 |
| 46 | F | 44 | PC | 10.8 | 363 | 211 | 2.5 | Moderate | + | <25 |
| 47 | M | 60 | PC | 7.6 | 543 | 480 | 2.2 | Moderate | − | 31 |
↵* Reincke classification (8).
NF = no functioning adenoma; ACTH = adrenocorticotropin; UFC = 24-h urinary free cortisol; BMI = body mass index.