Comparison of Hypometabolic Patterns in Temporal Lobe Between Medial TLE and Lateral TLE
| Temporal structure | Medial TLE | Lateral TLE | P value |
|---|---|---|---|
| Presence of significant hypometabolism at P < 0.001*† | |||
| Ipsilateral temporal lobe | 76% (59/78) | 77% (27/35) | NS |
| Both medial and lateral T structures | 59% (35/59) | 33% (9/27) | |
| Lateral T structure only | 36% (21/59) | 67% (18/27) | 0.02 |
| Medial T structure only | 5% (3/59) | 0 | |
| Contralateral temporal lobe | 32% (25/78) | 34% (12/35) | NS |
| Both medial and lateral T structures | 16% (4/25) | 17% (2/12) | |
| Lateral T structure only | 56% (14/25) | 83% (10/12) | |
| Medial T structure only | 28% (7/25) | 0 | |
| Extent of hypometabolism† (no. of significant voxels at P < 0.001) | |||
| Entire T area | 1,165 ± 1,239 | 845 ± 884 | NS |
| Lateral T structure | 924 ± 982 | 743 ± 760 | NS |
| Medial T structure | 241 ± 343 | 102 ± 239 | 0.03 |
| Severity of hypometabolism (ASI) | |||
| Entire T area | 9.02 ± 6.57 | 6.06 ± 8.68 | 0.081 |
| Lateral T structure | 9.29 ± 7.19‡ | 6.52 ± 9.64§ | NS |
| Medial T structure | 7.81 ± 4.89‡ | 3.39 ± 5.44§ | <0.001 |
| Hippocampus | 10.7 ± 6.42 | 3.30 ± 6.66 | <0.001 |
↵* Presence of significant hypometabolism in each VOI at P value of 0.001 with minimum of 100 contiguous significant voxels in lateral temporal structures or 50 contiguous voxels in medial temporal structures.
↵† P value from comparison between medial TLE and lateral TLE groups.
↵‡ P = 0.04.
↵§ P = 0.02.
T = temporal; NS = nonsignificant.