Dosimetric Data for Intravenously Administered 99mTc-HYNIC-AnxV
| Site | Uptake* (%ID) | Effective half-life† (h) | Residence time (h) | Absorbed dose (μGy/MBq) | Absorbed dose, Apomate‡ (μGy/MBq) | Absorbed dose, 99mTc-i-AnxV§ (μGy/MBq) |
|---|---|---|---|---|---|---|
| Kidneys | 49.7 ± 8.1‖ | 5.9 ± 0.1 | 3.90 ± 0.63 | 196 ± 31 | 63 ± 22 | 93 ± 24 |
| Liver | 13.1 ± 1.0‖ | 5.9 ± 0.1 | 1.03 ± 0.10 | 16.9 ± 1.3 | 13 ± 3 | 17 ± 2 |
| Red bone marrow | 9.2 ± 1.8 | 6.0 ± 0.1 | 0.78 ± 0.15 | 8.4 ± 0.9 | 4.0 ± 0.7 | 5.5 ± 0.8 |
| Spleen | 4.6 ± 1.6 | 5.7 ± 0.4 | 0.36 ± 0.13 | 41 ± 12 | 15 ± 3 | 22 ± 6 |
| Testes (n = 6) | 0.16 ± 0.04 | 4.6 ± 0.3 | 0.014 ± 0.003 | 5.3 ± 0.9 | 6.3 ± 1.6 | 15 ± 3 |
| Thyroid | 0.14 ± 0.08 | 4.4 ± 0.7 | 0.011 ± 0.005 | 7.1 ± 3.2 | 5.6 ± 3.6 | 10 ± 6 |
| Urinary bladder¶ | — | — | 0.15 ± 0.01 | 7.5 ± 0.4 | 20 ± 6 | 7.5 ± 2.6 |
| Remainder | — | — | 1.58 ± 0.81 | — | — | — |
| Total body | 91.6 ± 1.7 | 5.5 ± 0.1 | 7.82 ± 0.08 | 11.0 ± 0.8# | 7.6 ± 0.5# | 9.7 ± 1.0# |
↵* Uptake values are at 3 h after injection and are corrected for physical decay.
↵† Results are from a fit with a single exponential.
↵‡ (10).
↵§ (9).
↵‖ Including correction for overlap between right kidney and liver; see text.
↵¶ Dynamic bladder model (20); 4-h voiding interval; biologic half-life of activity in total body from individual measurements (average, 69 ± 7 h); fraction of activity to urine = 1.0.
↵# Effective dose (ICRP 60) in μSv/MBq.
Data are mean ± SD (n = 6).