TABLE 3

Effect of Diatrizoate Meglumine and Iohexol on Radioiodide Thyroid Uptake

GroupDay 1*†Day 8*†Day 15*†Day 22*†
Control10.1 ± 0.510.2 ± 1.010.2 ± 0.79.8 ± 0.8
Diatrizoate meglumine
 1 mL/kg (282 mg I/kg)‡4.5 ± 0.47.2 ± 0.79.6 ± 0.89.1 ± 1.0
 2 mL/kg (564 mg I/kg)‡3.9 ± 0.36.6 ± 0.69.9 ± 0.810.0 ± 1.8
Iohexol
 1 mL/kg (300 mg I/kg)‡3.2 ± 0.25.0 ± 0.79.4 ± 1.09.4 ± 0.4
 2 mL/kg (600 mg I/kg)‡3.0 ± 0.34.6 ± 0.67.6 ± 0.69.2 ± 1.2

  • ↵* Radioiodide administered 24 h before determination of thyroid uptake.

  • ↵† Time after termination of administration of interfering agent.

  • ↵‡ Milligrams of organic iodide.

  • Data are expressed as percentage radioiodide thyroid uptake (mean ± SD; n = 5 rats per group).