Pharmacokinetics of 111In-DOTA-8-Aoc-BBN[7–14]NH2 Analog in PC-3 Tumor–Bearing SCID Mice
| Tissue | 15 min | 30 min | 1 h | 1 h blocking | 4 h | 24 h | 48 h | 72 h |
|---|---|---|---|---|---|---|---|---|
| Blood | 5.59 ± 2.43 | 1.46 ± 0.44 | 0.60 ± 0.39 | 0.68 ± 0.19 | 0.27 ± 0.02 | 0.10 ± 0.03 | 0.07 ± 0.03 | 0.01 ± 0.02 |
| Heart | 2.20 ± 1.05 | 0.62 ± 0.33 | 0.25 ± 0.18 | 0.28 ± 0.17 | 0.13 ± 0.06 | 0.05 ± 0.09 | 0.05 ± 0.05 | 0.01 ± 0.01 |
| Lung | 3.35 ± 1.22 | 0.94 ± 0.28 | 0.50 ± 0.39 | 0.79 ± 0.26 | 0.25 ± 0.08 | 0.09 ± 0.07 | 0.06 ± 0.02 | 0.02 ± 0.02 |
| Liver | 2.03 ± 0.85 | 0.70 ± 0.21 | 1.34 ± 0.25 | 0.79 ± 0.15 | 1.44 ± 0.57 | 0.37 ± 0.12 | 0.13 ± 0.04 | 0.07 ± 0.02 |
| Spleen | 2.21 ± 0.80 | 0.83 ± 0.26 | 1.39 ± 1.17 | 0.21 ± 0.15 | 1.59 ± 0.27 | 0.46 ± 0.20 | 0.22 ± 0.22 | 0.08 ± 0.09 |
| Stomach | 3.30 ± 1.99 | 1.82 ± 0.44 | 1.99 ± 0.24 | 0.34 ± 0.12 | 0.96 ± 0.57 | 0.30 ± 0.05 | 0.12 ± 0.03 | 0.05 ± 0.02 |
| Large intestine | 8.58 ± 3.04 | 4.33 ± 0.44 | 4.29 ± 2.55 | 0.21 ± 0.06 | 10.30 ± 2.70 | 2.35 ± 0.43 | 0.81 ± 0.20 | 0.45 ± 0.04 |
| Small intestine | 7.82 ± 2.26 | 5.16 ± 1.06 | 6.80 ± 1.81 | 2.19 ± 0.43 | 2.24 ± 0.35 | 0.89 ± 0.16 | 0.25 ± 0.06 | 0.10 ± 0.02 |
| Kidney | 29.00 ± 14.40 | 8.70 ± 2.80 | 5.66 ± 1.33 | 3.40 ± 0.62 | 3.18 ± 0.43 | 1.18 ± 0.14 | 0.48 ± 0.09 | 0.20 ± 0.02 |
| Muscle | 1.30 ± 0.60 | 0.32 ± 0.12 | 0.08 ± 0.07 | 0.14 ± 0.10 | 0.04 ± 0.02 | 0.05 ± 0.05 | 0.02 ± 0.04 | 0.01 ± 0.02 |
| Pancreas | 54.30 ± 9.70 | 27.90 ± 3.40 | 18.80 ± 11.00 | 0.46 ± 0.07 | 16.60 ± 4.40 | 6.78 ± 1.15 | 0.77 ± 0.44 | 0.23 ± 0.08 |
| Tumor | 7.59 ± 2.11 | 4.58 ± 0.53 | 3.63 ± 1.11 | 1.32 ± 0.28 | 1.78 ± 1.09 | 1.56 ± 0.45 | 0.68 ± 0.24 | 0.34 ± 0.10 |
| Urine (%ID) | 27.9 ± 10.3 | 62.6 ± 5.0 | 68.6 ± 7.0 | 86.5 ± 1.9 | 81.8 ± 3.8 | 87.2 ± 4.3 | 91.8 ± 4.1 | 92.5 ± 1.1 |
Data are average %ID/g; n = 5.