111In-DOTA-X-BBN[7–14]NH2 Analog Biodistribution in CF1 Normal Mice at 1 Hour After Injection
| Analog tissue | No spacer | β-Ala | 5-Ava | 8-Aoc | 8-Aoc blocking | 11-Aun |
|---|---|---|---|---|---|---|
| Blood | 0.10 ± 0.03 | 0.11 ± 0.06 | 0.20 ± 0.07 | 0.32 ± 0.09 | 0.49 ± 0.15 | 0.34 ± 0.08 |
| Heart | 0.05 ± 0.02 | 0.06 ± 0.04 | 0.10 ± 0.04 | 0.05 ± 0.02 | 0.16 ± 0.06 | 0.13 ± 0.04 |
| Lung | 0.13 ± 0.03 | 0.11 ± 0.08 | 0.20 ± 0.06 | 0.31 ± 0.07 | 0.74 ± 0.17 | 0.26 ± 0.05 |
| Liver | 0.09 + 0.01 | 0.11 + 0.02 | 0.16 + 0.02 | 0.65 + 0.07 | 0.54 + 0.13 | 1.22 + 0.25 |
| Spleen | 0.08 ± 0.02 | 0.37 ± 0.06 | 0.87 ± 0.28 | 1.51 ± 0.41 | 0.15 ± 0.16 | 1.15 ± 0.38 |
| Stomach | 0.06 ± 0.03 | 0.30 ± 0.07 | 0.71 ± 0.24 | 1.02 ± 0.26 | 0.32 ± 0.34 | 1.05 ± 0.25 |
| Large intestine | 0.09 ± 0.03 | 1.10 ± 0.78 | 3.07 ± 0.86 | 2.66 ± 1.07 | 0.16 ± 0.06 | 4.34 ± 1.34 |
| Small intestine | 0.44 ± 0.64 | 1.01 ± 0.37 | 3.49 ± 0.87 | 4.43 ± 0.90 | 0.95 ± 0.18 | 11.12 ± 2.07 |
| Kidney | 1.24 ± 0.14 | 1.40 ± 0.27 | 1.84 ± 0.44 | 2.37 ± 0.31 | 2.19 ± 0.47 | 2.06 ± 0.31 |
| Muscle | 0.03 ± 0.02 | 0.03 ± 0.02 | 0.05 ± 0.02 | 0.12 ± 0.05 | 0.11 ± 0.07 | 0.09 ± 0.03 |
| Pancreas | 0.20 ± 0.04 | 4.92 ± 0.37 | 15.78 ± 2.54 | 26.97 ± 3.97 | 0.43 ± 0.10 | 26.00 ± 3.46 |
| Urine (%ID) | 97.0 ± 0.4 | 92.4 ± 0.9 | 81.3 ± 1.3 | 71.6 ± 1.8 | 88.2 ± 1.8 | 53.3 ± 0.9 |
Data are %ID/g; n = 5.