Biodistribution in Rats for Selected [99mTc(N)(PNP)(L)]+ Complexes
| Organ | % Dose/g for 3 rats at 60 min (mean ± SD) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [99mTc(N) (PNP3)(NOME)]+ | [99mTc(N) (PNP3)(BOET)]+ | [99mTc(N) (PNP3)(ISOET)]+ | [99mTc(N) (PNP3)(DPODC)]+ | [99mTc(N) (PNP5)(NOME)]+ | [99mTc(N) (PNP5)(BOET)]+ | [99mTc(N) (PNP5)(ISOET)]+ | |||||||
| Heart | 1.31 ± 0.05 | 2.84 ± 0.04 | 2.98 ± 0.19 | 2.26 ± 0.60 | 2.05 ± 0.31 | 2.69 ± 0.19 | 2.74 ± 0.19 | ||||||
| Blood | 0.01 ± 0.00 | 0.02 ± 0.00 | 0.01 ± 0.00 | 0.02 ± 0.01 | 0.02 ± 0.00 | 0.01 ± 0.00 | 0.02 ± 0.00 | ||||||
| Lungs | 0.21 ± 0.03 | 0.40 ± 0.07 | 0.42 ± 0.01 | 0.27 ± 0.09 | 0.29 ± 0.07 | 0.40 ± 0.06 | 0.35 ± 0.03 | ||||||
| Liver | 0.12 ± 0.02 | 0.26 ± 0.03 | 0.29 ± 0.07 | 0.42 ± 0.23 | 0.33 ± 0.05 | 0.47 ± 0.09 | 0.43 ± 0.15 | ||||||
| Kidneys | 1.93 ± 0.27 | 3.66 ± 0.50 | 4.52 ± 0.51 | 3.44 ± 0.76 | 3.02 ± 0.40 | 5.28 ± 0.58 | 5.12 ± 0.35 | ||||||
| Heart-to-lung uptake ratio | 6.24 | 7.10 | 7.10 | 8.37 | 7.07 | 6.73 | 7.83 | ||||||
| Heart-to-liver uptake ratio | 10.92 | 10.92 | 10.28 | 5.38 | 6.21 | 5.72 | 6.37 | ||||||