TABLE 2

Nonlinear Least Squares Fit and Graphical Analysis Parameters

Group	n	Nonlinear least squares fit
Group	n			k₁	k₂	k₃	k₄	V_B	Ki	Ki_[G]	Ki	Ki_[G]
Fasting
All groups	14	0.63 ± 0.14	0.78 ± 0.18	0.36 ± 0.19	0.23 ± 0.62	7 ± 8	0.29 ± 0.14	1.5 ± 0.7	0.22 ± 0.12	1.2 ± 0.6
Normal IS	7	0.62 ± 0.12	0.76 ± 0.15	0.43 ± 0.24	0.47 ± 0.83	12 ± 8	0.34 ± 0.18	1.8 ± 0.9	0.23 ± 0.14	1.3 ± 0.8
Low IS	7	0.64 ± 0.16	0.79 ± 0.22	0.29 ± 0.07	0.001 ± 0.0003	1 ± 1	0.23 ± 0.06	1.2 ± 0.3	0.21 ± 0.09	1.1 ± 0.5
Clamp
All groups	24	0.63 ± 0.19	0.79 ± 0.27	0.55 ± 0.24*	0.11 ± 0.33	10 ± 8	0.43 ± 0.15*	2.3 ± 0.9*	0.42 ± 0.18*	2.2 ± 0.9*
Normal IS	9	0.60 ± 0.16	0.74 ± 0.20	0.57 ± 0.25	0.02 ± 0.06*	13 ± 22	0.45 ± 0.18	2.3 ± 1.1	0.39 ± 0.16^†	2.0 ± 0.8
High IS	8	0.62 ± 0.21	0.77 ± 0.26	0.50 ± 0.17	0.001 ± 0.0003*	6 ± 6	0.40 ± 0.13	2.0 ± 0.7	0.42 ± 0.14*	2.1 ± 0.8*
Low IS	7	0.68 ± 0.23	0.88 ± 0.36	0.59 ± 0.30*	0.34 ± 0.56	9 ± 16	0.44 ± 0.15*	2.4 ± 1.0*	0.45 ± 0.24*	2.4 ± 1.2*

↵* P ≤ 0.05 vs. fasting.
↵^† P = 0.07 vs. fasting.
Units of measure: k₁ = mL·min⁻¹·mL⁻¹ (tissue); k₂ = min⁻¹; k₃ = min⁻¹·10⁻²; k₄ = min⁻¹·10⁻⁴; Ki = mL·min⁻¹·100 mL⁻¹ (tissue); Ki_[G] = μmol·min⁻¹·100 mL⁻¹ (tissue).