Summary Diagnostic Performance of 18F-FDG PET for Diagnosing Malignant vs. Benign Soft-Tissue Lesions
| Diagnostic parameter | Case series (subjects) | Independent estimates (95% CI)* | Typical SROC estimates (sensitivity, specificity)† | ||||
|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | Unweighted | Weighted | ||||
| Qualitative visualization | 13 (398) | 88% (81–93) | 73% (56–86) | (90%, 73%) | (92%, 73%) | ||
| Primary lesions | 7 (231) | 95% (89–98) | 59% (38–78) | (95%, 59%) | (96%, 59%) | ||
| Recurrent lesions | 5 (146) | 81% (69–89) | 91% (81–96) | (74%, 91%) | (81%, 91%) | ||
| SUV ≥ 2.0 | 10 (208) | 76% (64–85) | 79% (71–86) | (92%, 79%) | (87%, 92%) | ||
| Primary lesions | 7 (157) | 79% (67–88) | 77% (67–85) | (93%, 77%) | (91%, 77%) | ||
| Recurrent lesions | 3 (51) | 63% (44–78) | 91% (71–98) | (70%, 91%) | (72%, 91%) | ||
| SUV ≥ 3.0 | 10 (208) | 58% (48–67) | 87% (79–92) | (90%, 87%) | (70%, 87%) | ||
| Primary lesions | 7 (157) | 60% (48–72) | 86% (77–92) | (82%, 86%) | (66%, 86%) | ||
| Recurrent lesions | 3 (51) | 52% (35–69) | 91% (71–98) | (62%, 91%) | (62%, 91%) | ||
| MRG ≥ 6.0 μmol/100 g/min | 4 (66) | 70% (54–82) | 73% (53–87) | (72%, 73%) | (74%, 73%) | ||
| Primary lesions | 3 (52) | 75% (57–87) | 72% (50–87) | (76%, 72%) | (76%, 72%) | ||
| Recurrent lesions | 1 (14) | 58% (29–83) | 100% (16–100) | NE | NE | ||