Ab | Radionuclide | D0 (10−3 × decays per cell)* | 10−3 × decays for 2.5 log kill† | MBq/mL (μCi/mL) for ∼2.5 log kill‡ |
---|---|---|---|---|
L243 | 125I | 10.5 ± 1.9 | 64.9 ± 1.5 | 0.222 (6) |
131I | 3.2 ± 0.1 | 21.5 ± 1.0 | 0.148 (4) | |
111In | 12.6 ± 1.6 | 117.4 ± 1.4 | 0.296 (8) | |
67Ga | 7.6 ± 0.6 | 45.4 ± 0.7 | 0.185 (5) | |
1F5 | 125I | 16.5 ± 4.9 | 103.7 ± 32.5 | 1.85 (50) |
131I | 3.3 ± 1.3 | 23.4 ± 7.0 | 0.74 (20) | |
111In | 23.5 ± 0.9 | 168.7 ± 12.6 | 2.22 (60) | |
67Ga | 8.2 ± 1.7 | 73.9 ± 2.6 | 2.59 (70) |
↵* D0 = dose required for 63% kill in linear part of semilogarithmic dose-response curve (13). It is expressed as cumulative disintegrations per cell over 5–6 d.
↵† Cumulative disintegrations (over 5–6 d) required for cell kill of 2.5 logarithms (fraction surviving, 0.00316), as calculated by interpolation from points on either side.
↵‡ Ab concentration that produced cell kill closest to 2.5 logarithms (fraction surviving, 0.00316).
Values shown are means ± SD of 2 or 3 experiments.