TABLE 4

⁹⁰Y Effective Half-Life, Biologic Half-Life, and ⁹⁰Y AUC Derived from ¹¹¹In Activity in Blood

Dose group			Parameter	n	Time (h)
MBq/kg	(mCi/kg)		Parameter	n		Median	Range
7.4	(0.2)	AUC	4	15	9–24
		Biologic t_1/2	4	34	18–60
		Effective t_1/2	4	23	14–32
11	(0.3)	AUC	43	23	3–54
		Biologic t_1/2	43	43	19–66
		Effective t_1/2	43	26	15–33
15	(0.4)	AUC	98	27	3–102
		Biologic t_1/2	98	47	22–140
		Effective t_1/2	98	28	17–44
All			AUC	145	25	3–102
		Biologic t_1/2	145	46	18–140
		Effective t_1/2	145	27	14–44