Clinical Characteristics
| Characteristic | CRD patients | Disease control subjects | ||
|---|---|---|---|---|
| n | 42 | 33 | ||
| Sex (M/F) | 35/7 | 24/9 | ||
| Age (y) | 68.1 ± 7.7 | 65.1 ± 11.1 | ||
| Height (cm) | 161 ± 8 | 159 ± 7 | ||
| Weight (kg) | 53.9 ± 10.3 | 60.5 ± 9.4* | ||
| Origin of lung disease (%) | ||||
| COPD | 19 (45.2) | — | ||
| Tuberculosis sequela | 14 (33.3) | — | ||
| IIP | 2 (5.0) | — | ||
| Other† | 7 (17.5) | — | ||
| Risk factor (%) | ||||
| Hypertension | 23 (54.8) | 19 (57.6) | ||
| Hyperlipidemia | 9 (22.5) | 11 (33.3) | ||
| Diabetes mellitus | 7 (16.7) | 11 (33.3) | ||
| Smoking | 32 (76.2) | 16 (48.5)* | ||
| Pulmonary function test | Not done | |||
| VC (L) | 2.33 ± 0.89 | — | ||
| FEV1 (L) | 1.33 ± 0.57 | — | ||
| Dlco (%) | 67.4 ± 32.7 | — | ||
| CPET by treadmill‡ | Not done | |||
| Vo2 (mL/kg/min) | 17.5 ± 4.9 | — | ||
| Pao2 (mm Hg) | 61.6 ± 13.5 | — | ||
| HR/THR (%) | 86.6 ± 14.4 | — | ||
| Double product | 25,566 ± 6,281 | — | ||
| Myocardial perfusion imaging by upright ergometer‡ | ||||
| HR/THR | 85.8 ± 13.8 | 98.3 ± 22.5* | ||
| Double product | 24,828 ± 6,331 | 30,384 ± 7,255* | ||
↵* P < 0.05.
↵† Origins of lung disease in patients designated as Other were post lung cancer surgery (2 patients), pneumoconiosis (2 patients), bronchiectasis (1 patient), pyothorax (1 patient), and giant bulla (1 patient).
↵‡ At peak exercise.
IIP = idiopathic interstitial pneumonia; VC = vital capacity; FEV1 = forced expiratory volume in 1 s; Dlco = diffusing capacity of lung for carbon monoxide; Vo2 = volume of oxygen; Pao2 = partial pressure of oxygen, arterial; HR/THR = heart rate/target heart rate.
Data are presented as mean ± SD or % of patients.