Biodistribution of 18F-FA-4 and 11C-pipzA-4 in Normal Mice at 2, 10, and 30 Minutes After Injection
| Biodistribution | %ID | %ID/g | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 min | 10 min | 30 min | 2 min | 10 min | 30 min | ||||||
| 18F-FA-4 | |||||||||||
| Urine | 0.6 ± 0.1 | 1.3 ± 0.6 | 2.2 ± 0.6 | ||||||||
| Kidneys | 6.3 ± 2.1 | 9.2 ± 2.9 | 8.9 ± 1.0 | 8.3 ± 2.5 | 12.7 ± 4.8 | 11.7 ± 2.9 | |||||
| Liver | 11.5 ± 0.2 | 17.0 ± 3.7 | 18.5 ± 1.6 | 5.0 ± 0.9 | 7.0 ± 1.1 | 8.6 ± 1.0 | |||||
| Lungs | 28.4 ± 2.9 | 15.8 ± 3.1 | 9.9 ± 2.3 | 95.1 ± 9.8 | 45.8 ± 8.1 | 33.6 ± 9.1 | |||||
| Heart | 2.7 ± 0.3 | 2.5 ± 0.7 | 1.9 ± 0.3 | 13.7 ± 1.7 | 11.7 ± 2.0 | 9.3 ± 1.5 | |||||
| Cerebrum | 1.0 ± 0.2 | 1.3 ± 0.2 | 1.1 ± 0.1 | 3.0 ± 0.6 | 3.6 ± 0.3 | 3.4 ± 0.3 | |||||
| Cerebellum | 0.3 ± 0.0 | 0.4 ± 0.1 | 0.4 ± 0.1 | 2.3 ± 0.3 | 2.9 ± 0.3 | 2.9 ± 0.6 | |||||
| Blood | 8.1 ± 0.8 | 2.4 ± 0.1 | 1.0 ± 0.2 | 2.4 ± 0.3 | 0.7 ± 0.1 | 0.4 ± 0.1 | |||||
| 11C-pipzA-4 | |||||||||||
| Urine | 0.1 ± 0.0 | 0.5 ± 0.1 | 2.6 ± 1.1 | ||||||||
| Kidneys | 10.0 ± 1.8 | 7.7 ± 1.5 | 10.9 ± 1.0 | 17.6 ± 2.2 | 13.5 ± 5.5 | 19.2 ± 2.2 | |||||
| Liver | 8.9 ± 1.7 | 13.2 ± 1.5 | 14.7 ± 1.5 | 5.5 ± 1.2 | 8.1 ± 1.2 | 8.9 ± 0.4 | |||||
| Lungs | 20.8 ± 1.6 | 18.3 ± 3.1 | 11.5 ± 2.6 | 87.3 ± 3.1 | 60.7 ± 9.9 | 45.3 ± 7.2 | |||||
| Heart | 2.2 ± 0.3 | 1.8 ± 0.3 | 1.6 ± 0.2 | 20.2 ± 3.3 | 17.8 ± 0.6 | 14.6 ± 1.5 | |||||
| Cerebrum | 0.5 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | 1.8 ± 0.5 | 2.3 ± 0.1 | 2.2 ± 0.2 | |||||
| Cerebellum | 0.2 ± 0.0 | 0.3 ± 0.0 | 0.3 ± 0.0 | 1.8 ± 0.5 | 2.2 ± 0.3 | 2.1 ± 0.2 | |||||
| Blood | 6.1 ± 0.7 | 3.0 ± 0.2 | 1.3 ± 0.4 | 3.0 ± 0.3 | 1.6 ± 0.2 | 0.7 ± 0.1 | |||||
Data are expressed as mean ± SD; n = 5.