TABLE 1

Comparative Biodistributions of ⁸⁸Y-DOTA-hLL2 and ⁸⁸Y-Mx-DTPA-hLL2 for All Major Organs in Normal Female BALB/c Mice Until 10 Days After Injection of Conjugates

Tissue	Label	%ID/g of tissue ± SD (n = 5)
Tissue	Label			24 h	72 h	120 h	168 h	240 h
Liver	⁸⁸Y-DOTA	7.25 ± 0.53	6.32 ± 0.31	5.62 ± 0.19	4.93 ± 0.34	4.27 ± 0.43
	⁸⁸Y-Mx-DTPA	7.92 ± 0.99	7.71 ± 0.90	6.40 ± 0.45	6.44 ± 0.36	4.82 ± 0.30
Spleen	⁸⁸Y-DOTA	6.30 ± 0.31	7.56 ± 1.86	7.15 ± 0.57	8.68 ± 0.49	6.15 ± 2.33
	⁸⁸Y-Mx-DTPA	7.69 ± 1.33	6.80 ± 1.02	6.56 ± 1.06	7.64 ± 1.21	7.62 ± 0.65
Kidney	⁸⁸Y-DOTA	5.55 ± 1.06	4.18 ± 0.40	4.46 ± 1.02	4.76 ± 0.08	3.48 ± 0.17
	⁸⁸Y-Mx-DTPA	5.38 ± 1.28	5.93 ± 0.70	5.67 ± 1.36	5.16 ± 0.30	4.53 ± 0.31
Lung	⁸⁸Y-DOTA	5.98 ± 1.16	5.10 ± 0.71	5.27 ± 0.66	5.02 ± 0.68	4.27 ± 1.09
	⁸⁸Y-Mx-DTPA	7.25 ± 1.96	6.47 ± 0.61	5.54 ± 0.84	6.15 ± 0.65	5.74 ± 0.48
Blood	⁸⁸Y-DOTA	24.41 ± 1.7	20.86 ± 2.1	17.26 ± 0.5	14.30 ± 0.5	13.28 ± 2.1
	⁸⁸Y-Mx-DTPA	24.33 ± 1.6	20.72 ± 1.5	15.90 ± 0.7	14.12 ± 0.7	10.56 ± 0.6
Stomach	⁸⁸Y-DOTA	1.26 ± 0.51	1.04 ± 0.29	1.51 ± 0.11	1.31 ± 0.18	1.16 ± 0.37
	⁸⁸Y-Mx-DTPA	1.78 ± 0.26	1.36 ± 0.40	1.59 ± 0.11	0.90 ± 0.23	1.01 ± 0.08
Small intestine	⁸⁸Y-DOTA	2.30 ± 0.24	2.08 ± 0.28	2.32 ± 0.18	1.97 ± 0.14	1.66 ± 0.17
	⁸⁸Y-Mx-DTPA	2.82 ± 0.35	2.55 ± 0.09	2.53 ± 0.17	1.88 ± 0.09	1.65 ± 0.11
Large intestine	⁸⁸Y-DOTA	1.59 ± 0.19	1.67 ± 0.17	1.69 ± 0.32	1.22 ± 0.11	0.89 ± 0.24
	⁸⁸Y-Mx-DTPA	1.78 ± 0.18	2.05 ± 0.51	1.56 ± 0.07	1.32 ± 0.15	1.04 ± 0.11
Bone	⁸⁸Y-DOTA	3.23 ± 0.46	3.12 ± 0.63	3.08 ± 0.46	2.95 ± 0.40	2.63 ± 0.38
	⁸⁸Y-Mx-DTPA	4.41 ± 0.81	5.68 ± 0.60	6.12 ± 0.78	8.43 ± 1.94	6.82 ± 0.57
Washed bone	⁸⁸Y-DOTA	2.22 ± 0.90	1.64 ± 0.52	1.58 ± 0.25	1.72 ± 0.22	1.36 ± 0.33
	⁸⁸Y-Mx-DTPA	2.64 ± 0.50	4.69 ± 1.10	5.26 ± 0.60	7.75 ± 1.85	5.30 ± 0.84