TABLE 2

%ID/g Values and Target-to-Background (LS174T/Organ) Ratios Derived from Ex Vivo Counting of Weighed Tissues in γ-Counter After 18-Hour Uptake Time

Tissue%ID/gRatio
Minibody (n = 5)Diabody (n = 4)Minibody (n = 5)Diabody (n = 4)
LS174T20.55 ± 2.744.53 ± 0.50*
C61.87 ± 0.38†0.23 ± 0.03*‡26.19 ± 11.1621.31 ± 4.47
Heart1.78 ± 0.21†0.07 ± 0.01*‡18.93 ± 6.1061.57 ± 7.84*
Liver1.18 ± 0.18†0.15 ± 0.01*‡31.05 ± 9.9131.16 ± 3.46
Kidney1.51 ± 0.22†0.37 ± 0.05*‡25.73 ± 9.8712.66 ± 2.17

  • ↵* Significantly different from minibody (P < 0.05, unpaired t test).

  • ↵† Significantly different from LS174T (minibody group; P < 0.05, paired t test).

  • ↵‡ Significantly different from LS174T (diabody group; P < 0.05, paired t test).

  • Data are mean ± SEM.