Tissue-to-Cerebellum Ratios After Pretreating Rats with Monoamine Transporter Inhibitors
| Region | Control (saline) | (+)McN5652 | Methylphenidate | Nisoxetine |
|---|---|---|---|---|
| Cerebellum | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 |
| Striatum | 6.48 ± 1.10 | 1.42 ± 0.03 | 5.12 ± 0.31 | 5.11 ± 0.56 |
| Hippocampus | 4.94 ± 0.34 | 1.77 ± 0.13 | 4.30 ± 0.15 | 4.36 ± 0.40 |
| Cortex | 2.86 ± 0.24 | 1.19 ± 0.10 | 2.82 ± 0.58 | 2.37 ± 0.45 |
| Hypothalamus | 10.66 ± 2.45 | 1.52 ± 0.39 | 6.94 ± 0.71 | 6.93 ± 0.53 |
(+)McN5652 = serotonin transporter inhibitor; methylphenidate = dopamine transporter inhibitor; nisoxetine = norepinephrine transporter inhibitor.
Data are % dose per gram; average of 3 rats ± SD. Rats were pretreated with drugs (2 mg/kg, 250 μL, intravenously) 5 min before tracer administration (intravenous) and sacrificed 2 h after tracer injection.