TABLE 1

Selectivity of Ligands for Monoamine Transporters (Ki, nmol/L)

LigandSERTDATNET
4-F-ADAM0.081 ± 0.006*2,267 ± 188*117 ± 23*
(4.8 ± 1.3)(5,358 ± 1,959)(137.2 ± 23.2)
(+)McN56520.009 ± 0.002*112 ± 23*11.3 ± 3.3*
AFM1.8 ± 0.32,055 ± 91795.5 ± 33.8
ADAM0.013 ± 0.003*840 ± 100*699 ± 80*
DASB1.10 ± 0.041,423 ± 1031,350 ± 221
  • * Expressed in LLC-PK1 cells.

  • Expressed in cloned human transporters (24).

  • Expressed in cloned human transporters (21).