TABLE 2

Normal Rat Distributions of 2 Kinds of 100-nm ¹⁸⁶Re-Liposomes Labeled with ¹⁸⁶Re-BMEDA and ¹⁸⁶Re-BMEDA Alone at 72 Hours (n = 4)

Organ	%ID per organ (mean ± SD)					%ID per gram (mean ± SD)
Organ		¹⁸⁶Re-Cysteine liposomes	¹⁸⁶Re-(NH₄)₂SO₄ liposomes	¹⁸⁶Re-BMEDA alone	¹⁸⁶Re-Cysteine liposomes	¹⁸⁶Re-(NH₄)₂SO₄ liposomes	¹⁸⁶Re-BMEDA alone
Spleen	3.88 ± 0.44*	9.80 ± 0.93*	0.21 ± 0.05	12.03 ± 1.51	32.50 ± 6.17	0.38 ± 0.14
Blood	0.32 ± 0.05^†	0.52 ± 0.11	0.49 ± 0.04	0.013 ± 0.001	0.020 ± 0.004	0.022 ± 0.001
Liver	8.55 ± 0.61*	22.75 ± 0.43*	5.97 ± 0.35	0.71 ± 0.08	1.82 ± 0.26	0.54 ± 0.05
Kidney	5.22 ± 0.48*	8.83 ± 0.09^‡	10.42 ± 0.93	2.02 ± 0.26	3.43 ± 0.44	4.49 ± 0.37
Lung	0.12 ± 0.02	0.16 ± 0.02	0.37 ± 0.06	0.060 ± 0.021	0.087 ± 0.018	0.23 ± 0.03
Heart	0.027 ± 0.004	0.035 ± 0.002	0.076 ± 0.005	0.022 ± 0.004	0.028 ± 0.004	0.069 ± 0.007
Brain	0.0026 ± 0.0006	0.0037 ± 0.0008	0.0052 ± 0.0007	0.0016 ± 0.0003	0.0024 ± 0.0003	0.0035 ± 0.0007
Muscle	0.57 ± 0.14	1.01 ± 0.30^‡	0.79 ± 0.07	0.0032 ± 0.0009	0.0054 ± 0.0019	0.0048 ± 0.0005
Bone and marrow	1.28 ± 0.20*	6.14 ± 1.00*	0.58 ± 0.06	0.028 ± 0.004	0.13 ± 0.03	0.014 ± 0.000
Skin	0.84 ± 0.22	1.44 ± 0.28	1.48 ± 0.51	0.014 ± 0.004	0.023 ± 0.005	0.029 ± 0.012
Testis	0.044 ± 0.014	0.082 ± 0.011	0.058 ± 0.004	0.012 ± 0.005	0.022 ± 0.004	0.015 ± 0.003
Feces	6.08 ± 0.57	16.26 ± 6.36	20.54 ± 4.35	1.83 ± 0.65	3.63 ± 0.49	4.82 ± 1.53
Bowel	5.38 ± 1.44	12.37 ± 3.58	6.67 ± 3.31	0.24 ± 0.05	0.52 ± 0.14	0.34 ± 0.19
Urine	50.09 ± 15.30^‡	11.33 ± 0.50*	26.93 ± 4.23	1.06 ± 0.47	0.39 ± 0.09	0.79 ± 0.08

↵* P < 0.001 compared with ¹⁸⁶Re-BMEDA alone.
↵^† P < 0.01 compared with ¹⁸⁶Re-BMEDA alone.
↵^‡ P < 0.05 compared with ¹⁸⁶Re-BMEDA alone.
¹⁸⁶Re-Cysteine liposomes have significantly lower total feces and bowel radioactivity level compared with ¹⁸⁶Re-BMEDA alone (P < 0.001).