TABLE 3

Comparison of ¹⁴C-ACPC, ¹⁸F-FDG, and ⁶⁷Ga-DTPA Uptake in Morphologically Distinct Intratumoral Regions

Tissue	Untreated (saline)					Treated (GCV)
Tissue		¹⁴C-ACPC	⁶⁷Ga-DTPA	¹⁸F-FDG	¹⁴C-ACPC	⁶⁷Ga-DTPA	¹⁸F-FDG
Viable tumor
High cell density	1.28 ± 0.32 (5)	1.28 ± 0.19 (5)*	1.23 ± 0.17 (5)*	1.04 ± 0.13 (6)	1.01 ± 0.26 (6)	1.20 ± 0.13 (5)*
Low cell density	0.89 ± 0.12 (5)	0.99 ± 0.24 (5)	0.96 ± 0.07 (5)	0.98 ± 0.07 (6)	0.87 ± 0.14 (6)*	0.86 ± 0.10 (5)
Impending necrosis	1.43 ± 0.22 (4)*	1.71 ± 0.81 (4)	1.44 ± 0.07 (4)*	1.97 ± 0.28 (4)	2.22 ± 0.99 (4)	1.35 ± 0.35 (4)
Necrotic tumor
Necrosis	—	—	—	0.29 ± 0.27 (5)^†	0.62 ± 0.45 (5)^†	0.38 ± 0.10 (4)^†

↵* Statistically significant values, paired t test (P < 0.05).
↵^† Statistically significant values, paired t test (P < 0.01).
Tumor region-to-mean tumor ratio was calculated; values are mean ± SD; number of animals is given in parenthesis.