Characteristic | COPD patients (n = 25) | Control subjects (n = 12) | P value* |
---|---|---|---|
Age (y) | 72.6 ± 8.3 | 70.0 ± 11.0 | NS |
FVC (L) | 2.25 ± 0.77 | 3.63 ± 0.72 | <0.0001 |
% FVC | 71.1 ± 22.3 | 112.0 ± 15.9 | <0.0001 |
FEV1.0 (L) | 0.96 ± 0.52 | 2.88 ± 0.65 | <0.0001 |
% FEV1.0 | 45.1 ± 23.5 | 127.1 ± 21.1 | <0.0001 |
FEV1.0/FVC (%) | 41.6 ± 10.9 | 79.0 ± 4.4 | <0.0001 |
DLCO/VA (mL/min/mm Hg/L) | 2.43 ± 1.07 | 3.67 ± 1.07 | <0.01 |
% DLCO/VA | 56.2 ± 24.6 | 82.3 ± 19.2 | <0.01 |
Arterial Po2 (mm Hg) | 67.4 ± 12.3 | 83.4 ± 9.8 | <0.01 |
Arterial Pco2 (mm Hg) | 47.7 ± 7.4 | 41.9 ± 2.1 | <0.01 |
[A–a]Do2 (mm Hg) | 25.2 ± 11.2 | 16.1 ± 10.1 | <0.05 |
% LAA | 15.5 ± 12.0 | 2.7 ± 4.3 | <0.0001 |
↵* Mann–Whitney U test.
NS = not significant; % FVC = percentage of predicted values of FVC; % FEV1.0 = percentage of predicted values of FEV1.0; % DLCO/VA = percentage of predicted values of DLCO/VA; [A–a]Do2 = alveolar–arterial oxygen tension gradient; % LAA = percentage ratio of low-attenuation area to corresponding lung area.
Values are presented as mean ± SD.