TABLE 3

Summary of LS174T Tumor Growth in Athymic Mice After Combination ¹³¹I-B72.3 RIT with 2 Doses of AP

Parameter	0.1 mg AP control	9.25 MBq ¹³¹I-B72.3 plus
Parameter	0.1 mg AP control			0 mg AP control	2 × 0.01 mg AP	2 × 0.1 mg AP
Initial tumor size* (mm³)	76 ± 15	97 ± 36	55 ± 8	71 ± 19
Tumor size on day 15* (mm³)	1,941 ± 315	466 ± 249	156 ± 78	121 ± 40
Tumor T_q* (d)	7.1 ± 0.4	15.5 ± 3.1	34.7 ± 6.0^†	48.5 ± 7.9^‡
Specific growth delay^§	0	1.2	3.9	5.8

↵* Mean ± SE.
↵^† Two tumors regressed to 25% and 30% initial volume.
↵^‡ Two tumors regressed to 10% and 93% initial volume.
↵^§ Specific growth delay = (T_q treated − T_q control)/T_q control (11).