TABLE 2

Organ Uptake of Unconjugated HD-PNA or HD-PNA/8D3 Conjugate at 60 Minutes After Intravenous Administration in Either BALB/c or R6/2 Mice

OrganBALB/cR6/2
125I-HD-PNA125I-HD-PNA/8D3125I-HD-PNA/8D3
Liver0.96 ± 0.0229 ± 240 ± 2
Kidney36 ± 514 ± 110 ± 3
Heart0.56 ± 0.051.2 ± 0.12.1 ± 0.1
Lung2.1 ± 0.37.0 ± 0.78.6 ± 0.1
Spleen0.64 ± 0.0980 ± 467 ± 5
Thyroid1.2 ± 0.4
Stomach2.5 ± 0.1
  • Data are mean (±SE) %ID/g (n = 3 mice).