TABLE 1

Pharmacokinetic Parameters

ParameterUnit125I-HD-PNA/8D3125I-HD-PNA
A1%ID/mL35 ± 232 ± 2
A2%ID/mL20 ± 16.3 ± 0.7
K11/min0.49 ± 0.040.37 ± 0.04
K21/min0.0102 ± 0.00080.0206 ± 0.0014
t1/21min1.4 ± 0.11.9 ± 0.2
t1/22min68 ± 534 ± 3
AUC (60 min)%ID·min/mL970 ± 47308 ± 36
AUC (∞)%ID·min/mL2,048 ± 165399 ± 49
VSSmL/kg176 ± 8374 ± 42
CLmL/min/kg1.9 ± 0.19.7 ± 1.3
  • Data are mean ± SE computed by nonlinear regression analysis of serum radioactivity measured at 0.25, 2, 5, 15, and 60 min after intravenous injection of either unconjugated 125I-HD-PNA or 125I-HD-PNA/8D3 conjugate. Total of 30 mice were used to generate plasma profiles for either form of PNA. ID = injected dose.