Literature Summary of Probes for Imaging HSV1-tk Gene Expression
| Radiolabeled probe | Chemical name | References |
|---|---|---|
| Pyrimidine derivatives | ||
| FIAU (123I, 124I, 125I, 131I) | 2′-Fluoro-2′-deoxy-1-β-d-arabinofuranosyl-5-iodouracil | 1–7, 22–24 |
| FIRU (125I) | 2′-Fluoro-2′-deoxy-5-iodo-1-β-d-ribofuranosyl-uracil | 22, 23 |
| FMAU (11C) | 2′-Fluoro-2′-deoxy-5-methyl-1-β-d-arabinofuranosyl-uracil | 25, 26 |
| IVFRU (123I, 125I, 131I) | 2′-Fluoro-2′-deoxy-5-iodovinyl-1-β-d-ribofuranosyl-uracil | 23, 27, 28 |
| IUdR (3H) | 2′-Deoxy-5-iodo-1-β-d-ribofuranosyl-uracil (iododeoxyuridine) | 1 |
| Acycloguanosine derivatives | ||
| ACV (8-14C, 8-3H) | 9-[(2-Hydroxy-1-ethoxy)methyl]guanine (acyclovir) | 11, 24 |
| GCV (8-14C, 8-3H) | 9-[(2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (ganciclovir) | 1, 10, 11 |
| PCV (8-3H) | 9-[4-Hydoxy-3-(hydoxymethyl)butyl]guanine (penciclovir) | 14, 15 |
| FGCV (8-18F) | 8-Fluoro-9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (fluoroganciclovir) | 12, 13 |
| FPCV (8-18F) | 8-Fluoro-9-[4-hydoxy-3-(hydoxymethyl)butyl]guanine (fluoropenciclovir) | 14, 15 |
| FHPG (3-18F) | 9-[3-Fluoro-1-hydoxy-2-propoxymethyl]guanine | 16, 17, 24, 25 |
| FHBG (4-18F) | 9-[4-Fluoro-3-(hydoxymethyl)butyl]guanine | 18, 19, 29 |
References relate primarily to probe comparisons; because of reference number limitation, complete listing of all references was not possible.