TABLE 2

Paired Comparisons of Probe Accumulation in HSV1-tk Transduced and Wild-Type RG2 Xenografts

Measurement	2 h*			2 h*
Measurement		FIAU	FHBG	FIAU	FHPG	FIAU
Xenograft difference^†
(RG2TK+) − (RG2)	1.12 ± 0.16	0.062 ± 0.043	1.11 ± 0.19	0.006 ± 0.010	1.50 ± 0.69
Xenograft ratio^‡
RG2TK+/RG2	11.3 ± 2.6	5.9 ± 2.3	8.9 ± 2.2	1.4 ± 0.7	65 ± 21
RG2TK+/muscle	18.1 ± 3.8	4.9 ± 2.2	16.9 ± 3.1	0.77 ± 0.44	124 ± 58

↵* Paired comparison from same animal tissue sampling dataset.
↵^† Background-corrected RG2TK+ value. Difference expressed as %dose/g tissue.
↵^‡ Concentration ratio.
Paired 2-sample t tests of FIAU 2 h vs. FHBG 2 h or FIAU 2 h vs. FHPG 2 h for (RG2TK+) − (RG2), RG2TK+/RG2, RG2TK+/muscle: P < 0.0001. Unpaired, 2-sample t tests of FIAU 2 h vs. 24 h for RG2TK+/RG2, RG2TK+/muscle: P < 0.0001. Unpaired, 2-sample t tests of FIAU 2 h vs. 24 h for (RG2TK+) − (RG2): P = not significant.