TABLE 1

Biodistribution of Different Probes for Imaging HSV1-tk Gene Expression

Tissue	FIAU, 2 h			FHBG, 2 h*			FHPG, 2 h*
Tissue		Mean ± SD	n	Mean ± SD	n	Mean ± SD	n	Mean ± SD	n
RG2TK+	1.217 ± 0.170	12	0.074^‡ ± 0.049	6	0.023^‡ ± 0.008	6	1.527^§ ± 0.399	11
RG2	0.112 ± 0.042	12	0.013^¶ ± 0.006	6	0.018^¶ ± 0.005	6	0.026^‡ ± 0.015	11
Plasma	0.244 ± 0.071	12	0.010^¶ ± 0.003	6	0.043^¶ ± 0.032	6	0.062^‡ ± 0.035	11
Muscle	0.070 ± 0.015	12	0.016^¶ ± 0.007	6	0.039^‖ ± 0.025	6	0.015^‡ ± 0.010	11
Liver	0.083 ± 0.028	12	0.026^¶ ± 0.012	6	0.038^¶ ± 0.020	6	0.018^‡ ± 0.009	5
Stomach	0.137 ± 0.040	12	0.014^¶ ± 0.004	6	0.016^¶ ± 0.007	6	0.210^§ ± 0.123	5
Heart	0.073 ± 0.017	12	0.006^¶ ± 0.003	6	0.012^‡ ± 0.004	6	0.011^‡ ± 0.007	5
Lung	0.165 ± 0.045	12	0.013^¶ ± 0.008	6	0.019^‡ ± 0.005	6	0.028^‡ ± 0.018	5
Kidney	0.249 ± 0.124	11	0.052^‖ ± 0.061	6	0.079^‖ ± 0.025	5	0.026^‡ ± 0.018	5
Small intestine	0.170 ± 0.035	12	0.038^¶ ± 0.025	6	0.029^¶ ± 0.025	6	0.076^‡ ± 0.026	5
Large intestine	0.170 ± 0.029	12	0.052^¶ ± 0.027	6	0.035^¶ ± 0.024	6	0.056^‡ ± 0.014	5
Thyroid	0.125 ± 0.039	12	0.010^¶ ± 0.004	6	0.016^¶ ± 0.004	6	0.022^‡ ± 0.014	5
Spleen	0.145 ± 0.047	12	0.021^¶ ± 0.010	6	0.026^‡ ± 0.009	6	0.027^‡ ± 0.010	5
Brain	0.029 ± 0.007	12	0.0009^¶ ± 0.0012	6	0.0027^¶ ± 0.0012	6	0.0011^‡ ± 0.0007	5

↵* Comparison of FHBG or FHPG vs. FIAU at 2 h by paired t test.
↵^† Comparison of FIAU at 24 h vs. 2 h by unpaired t test.
↵^‡ P < 0.0001.
↵^§ P = not significant.
↵^¶ 0.0001 < P < 0.0015.
↵^‖ 0.005 < P < 0.02.
Probability values are nominal significance levels for univariate tests unadjusted for multiple comparisons; P < 0.0001 and 0.0001 < P < 0.0015 remain significant even with conservative Bonferroni correction.