TABLE 4

Regional k₂ Values After Injection of (+)-¹¹C-McN5652 or ¹¹C-DASB

Radioligand*	Pons	MB	Hypo	Thalamus	Put	Cd	FC	PC	TC	CC	OC	Cereb
¹¹C-McN5652
Control	0.10 ± 0.00	0.06 ± 0.00	0.07 ± 0.01	0.08 ± 0.01	0.10 ± 0.00	0.10 ± 0.02	0.18 ± 0.01	0.19 ± 0.01	0.15 ± 0.01	0.15 ± 0.01	0.21 ± 0.02	0.21 ± 0.02
MDMA	0.15 ± 0.04^†	0.11 ± 0.03^†	0.13 ± 0.02^†	0.19 ± 0.01^†	0.24 ± 0.02^†	0.18 ± 0.02^†	0.30 ± 0.03^†	0.36 ± 0.03^†	0.23 ± 0.01^†	0.32 ± 0.03^†	0.42 ± 0.02^†	0.35 ± 0.03^†
Paroxetine	0.19 ± 0.04^†	0.17 ± 0.02^†^‡	0.20 ± 0.03^†	0.18 ± 0.02^†	0.18 ± 0.01^†	0.17 ± 0.01^†	0.18 ± 0.03^‡	0.20 ± 0.03^‡	0.14 ± 0.01^‡	0.19 ± 0.02^‡	0.21 ± 0.02^‡	0.23 ± 0.03^‡
¹¹C-DASB
Control	0.08 ± 0.03	0.05 ± 0.02	0.05 ± 0.01	0.07 ± 0.02	0.13 ± 0.03	0.10 ± 0.01	0.28 ± 0.07	0.34 ± 0.04	0.24 ± 0.03	0.24 ± 0.05	0.38 ± 0.06	0.40 ± 0.04
MDMA	0.11 ± 0.02	0.09 ± 0.00^†	0.11 ± 0.02^†	0.20 ± 0.00^†	0.31 ± 0.03^†	0.22 ± 0.02^†	0.45 ± 0.09	0.56 ± 0.07	0.34 ± 0.04^†	0.43 ± 0.06^†	0.61 ± 0.03^†	0.53 ± 0.05
Paroxetine	0.51 ± 0.03^†^‡	0.45 ± 0.02^†^‡	0.54 ± 0.02^†^‡	0.52 ± 0.03^†^‡	0.59 ± 0.06^†^‡	0.61 ± 0.06^†^‡	0.51 ± 0.05	0.54 ± 0.05	0.37 ± 0.03	0.52 ± 0.04^†	0.58 ± 0.06	0.68 ± 0.04^†

↵* Each radioligand was tested 3 times in control baboon or different baboon lesioned previously with serotonergic neurotoxin MDMA.
↵^† Designates significant difference from control (ANOVA without correction for multiple comparisons).
↵^‡ Designates significant difference from control (ANOVA with correction for multiple comparisons).
MB = midbrain; Hypo = hypothalamus; Put = putamen; Cd = caudate; FC = frontal cortex; PC = parietal cortex; TC = temporal cortex; CC = cingulate cortex; OC = occipital cortex; Cereb = cerebellum.
Values represent k₂ × 10 (mean ± SD [n = 3]).