TABLE 3

Regional K₁ Values After Injection of (+)-¹¹C-McN5652 or ¹¹C-DASB

Radioligand*	Pons	MB	Hypo	Thalamus	Put	Cd	FC	PC	TC	CC	OC	Cereb
¹¹C-McN5652
Control	0.29 ± 0.03	0.24 ± 0.02	0.30 ± 0.04	0.28 ± 0.01	0.24 ± 0.02	0.22 ± 0.02	0.23 ± 0.02	0.27 ± 0.02	0.23 ± 0.01	0.23 ± 0.01	0.30 ± 0.02	0.29 ± 0.02
MDMA	0.26 ± 0.04	0.25 ± 0.02	0.27 ± 0.02	0.28 ± 0.02	0.26 ± 0.02	0.21 ± 0.02	0.25 ± 0.05	0.31 ± 0.03	0.23 ± 0.02	0.29 ± 0.02	0.35 ± 0.03	0.30 ± 0.01
Paroxetine	0.27 ± 0.04	0.25 ± 0.05	0.30 ± 0.06	0.30 ± 0.07	0.32 ± 0.10	0.29 ± 0.08	0.24 ± 0.03	0.28 ± 0.04	0.21 ± 0.04	0.25 ± 0.06	0.30 ± 0.06	0.29 ± 0.05
¹¹C-DASB
Control	0.35 ± 0.02	0.30 ± 0.04	0.36 ± 0.05	0.33 ± 0.04	0.29 ± 0.01	0.27 ± 0.02	0.26 ± 0.03	0.31 ± 0.05	0.27 ± 0.04	0.27 ± 0.04	0.34 ± 0.03	0.37 ± 0.06
MDMA	0.30 ± 0.05	0.28 ± 0.02	0.32 ± 0.04	0.31 ± 0.05	0.28 ± 0.02	0.24 ± 0.02	0.27 ± 0.06	0.33 ± 0.06	0.24 ± 0.02	0.30 ± 0.05	0.37 ± 0.05	0.34 ± 0.06
Paroxetine	0.39 ± 0.05	0.36 ± 0.05	0.43 ± 0.08	0.42 ± 0.03	0.46 ± 0.06^†	0.46 ± 0.06^†	0.35 ± 0.05	0.39 ± 0.05	0.27 ± 0.02	0.37 ± 0.03	0.42 ± 0.05	0.47 ± 0.06

↵* Each radioligand was tested 3 times in control baboon or different baboon lesioned previously with serotonergic neurotoxin MDMA.
↵^† Designates significant difference from control (ANOVA without correction for multiple comparisons).
MB = midbrain; Hypo = hypothalamus; Put = putamen; Cd = caudate; FC = frontal cortex; PC = parietal cortex; TC = temporal cortex; CC = cingulate cortex; OC = occipital cortex; Cereb = cerebellum.
Values represent mean ± SD (n = 3).