TABLE 2

Regional DV Values After Injection of (+)-¹¹C-McN5652 or ¹¹C-DASB

Radioligand*	Pons	MB	Hypo	Thalamus	Put	Cd	FC	PC	TC	CC	OC	Cereb
¹¹C-McN5652
Control	29.4 ± 1.4	40.2 ± 2.7	46.1 ± 2.6	33.4 ± 1.2	23.6 ± 1.3	22.0 ± 1.4	12.9 ± 0.3	14.4 ± 0.5	15.5 ± 0.2	14.9 ± 0.5	14.3 ± 0.2	13.7 ± 0.3
MDMA	17.4 ± 1.2^†^‡	22.5 ± 2.5^†	21.2 ± 2.4^†^‡	14.4 ± 0.6^†^‡	11.2 ± 0.7^†^‡	11.8 ± 0.9^†^‡	8.2 ± 0.6^†^‡	8.6 ± 0.4^†^‡	10.0 ± 0.8^†^‡	9.2 ± 0.3^†^‡	8.4 ± 0.4^†^‡	8.7 ± 0.4^†^‡
Paroxetine	14.8 ± 3.2^†	15.3 ± 2.7^†^‡	15.3 ± 2.8^†	16.9 ± 3.3^†	18.3 ± 3.6	16.7 ± 3.1	13.2 ± 2.2	14.3 ± 2.4	15.1 ± 1.8	13.5 ± 2.5	14.3 ± 2.4	13.0 ± 2.3
¹¹C-DASB
Control	46.2 ± 11.1	71.3 ± 14.8	79.8 ± 11.2	45.5 ± 4.5	22.2 ± 3.3	27.5 ± 2.7	9.8 ± 1.3	9.2 ± 1.0	11.6 ± 1.4	11.5 ± 1.4	9.0 ± 0.9	9.2 ± 0.7
MDMA	26.5 ± 2.7	31.3 ± 1.4	31.3 ± 5.6^†	15.9 ± 1^†^‡	8.9 ± 0.9^†	11.5 ± 0.9^†	6.1 ± 0.2	5.9 ± 0.3^†	7.2 ± 0.7	6.9 ± 0.3^†	6.0 ± 0.3^†	6.3 ± 0.4^†
Paroxetine	7.7 ± 0.8^†^‖	7.9 ± 0.8^†^‖	8 ± 0.8^†^‡^‖	8.3 ± 0.6^†^‡^‖	7.9 ± 0.6^†	7.6 ± 0.7^†^‡^‖	6.9 ± 0.7	7.3 ± 0.5	7.4 ± 0.6	7.1 ± 0.6^†	7.3 ± 0.5	6.9 ± 0.7

↵* Each radioligand was tested 3 times in control baboon or different baboon lesioned previously with serotonergic neurotoxin MDMA.
↵^† Designates significant difference from control (ANOVA without correction for multiple comparisons).
↵^‡ Designates significant difference from control (ANOVA with correction for multiple comparisons).
↵^‖ Designates significant difference from MDMA (ANOVA without correction for multiple comparisons).
MB = midbrain; Hypo = hypothalamus; Put = putamen; Cd = caudate; FC = frontal cortex; PC = parietal cortex; TC = temporal cortex; CC = cingulate cortex; OC = occipital cortex; Cereb = cerebellum.
Values represent mean ± SD (n = 3).