TABLE 1

Average Regional Tissue Radioactivity Measured 75–95 Minutes After Injection of (+)-¹¹C-McN5652 or ¹¹C-DASB

Radioligand*	Pons	MB	Hypo	Thalamus	Put	Cd	FC	PC	TC	CC	OC	Cereb
¹¹C-McN5652
Control	139 ± 9	144 ± 19	165 ± 21	144 ± 21	113 ± 7	105 ± 7	75 ± 12	85 ± 5	87 ± 10	83 ± 9	86 ± 9	84 ± 7
MDMA	100 ± 3^†^‡	115 ± 3	117 ± 10^†	88 ± 12^†	70 ± 2^†^‡	73 ± 7^†	51 ± 5^†	52 ± 3^†^‡	63 ± 12^†	56 ± 5^†	50 ± 7^†	53 ± 3^†^‡
Paroxetine	94 ± 24^†	99 ± 14^†	98 ± 21^†	106 ± 22	115 ± 28^‖	105 ± 22	84 ± 12^‖	92 ± 14^‖	92 ± 10^‖	85 ± 19	93 ± 16^‖	86 ± 17^‖
¹¹C-DASB
Control	188 ± 24	194 ± 31	229 ± 33	185 ± 33	122 ± 16	136 ± 26	59 ± 3	56 ± 7	72 ± 9	72 ± 14	56 ± 5	55 ± 9
MDMA	117 ± 17^†	124 ± 16^†	134 ± 29^†	86 ± 16^†	49 ± 10^†^‡	62 ± 7^†	30 ± 2^†^‡	29 ± 2^†^‡	39 ± 9^†	36 ± 2^†	30 ± 3^†^‡	30 ± 3^†
Paroxetine	56 ± 9^†^‡^‖	54 ± 9^†^‡^‖	54 ± 5^†^‡^‖	56 ± 3^†^‡^‖	55 ± 2^†^‡	51 ± 5^†^‡	49 ± 5^†^‖	53 ± 3^‖	57 ± 3^†^‖	48 ± 3^†^‖	50 ± 5^‖	44 ± 5^‖

↵* Each radioligand was tested 3 times in control baboon or different baboon lesioned previously with serotonergic neurotoxin MDMA.
↵^† Designates significant difference from control (ANOVA without correction for multiple comparisons).
↵^‡ Designates significant difference from control (ANOVA with correction for multiple comparisons).
↵^‖ Designates significant difference from MDMA (ANOVA without correction for multiple comparisons).
MB = midbrain; Hypo = hypothalamus; Put = putamen; Cd = caudate; FC = frontal cortex; PC = parietal cortex; TC = temporal cortex; CC = cingulate cortex; OC = occipital cortex; Cereb = cerebellum.
Values represent mean ± SD (n = 3).