Radiation Dosimetry Estimates for Intravenous 18F-FCH Administration to Human Subjects on Basis of Murine and Human Biodistribution Data
| Organ or tissue | Murine data (dose per unit activity) | Human data (dose per unit activity) | ||||
|---|---|---|---|---|---|---|
| Female | Male | |||||
| mSv/MBq × 102 | rad/mCi | mSv/MBq × 102 | rad/mCi | mSv/MBq × 102 | rad/mCi | |
| Myocardium | 1.24 | 0.046 | 1.74 ± 0.31 | 0.064 ± 0.011 | 1.29 ± 0.16 | 0.048 ± 0.006 |
| Spleen | — | — | 6.37 ± 1.94 | 0.236 ± 0.072 | 4.73 ± 2.1 | 0.175 ± 0.079 |
| Small intestine | — | — | 2.57 ± 0.56 | 0.095 ± 0.021 | 2.10 ± 0.51 | 0.078 ± 0.019 |
| Uterus | — | — | 1.99 ± 0.35 | 0.074 ± 0.013 | — | — |
| Thyroid | — | — | 1.48 ± 0.34 | 0.055 ± 0.012 | 1.32 ± 0.16 | 0.049 ± 0.006 |
| Breast | — | — | 0.98 ± 0.22 | 0.036 ± 0.008 | — | — |
| Lung | 1.16 | 0.043 | 1.29 ± 0.15 | 0.048 ± 0.005 | 1.03 ± 0.30 | 0.038 ± 0.011 |
| Liver | 8.11 | 0.300 | 6.94 ± 0.41 | 0.257 ± 0.015 | 5.16 ± 0.86 | 0.191 ± 0.032 |
| Kidney | 21.90 | 0.810 | 17.35 ± 4.82 | 0.642 ± 0.178 | 14.8 ± 8.8 | 0.547 ± 0.324 |
| Bone | 1.03 | 0.038 | 2.18 ± 0.32 | 0.081 ± 0.012 | 1.73 ± 0.22 | 0.064 ± 0.008 |
| Muscle | 0.90 | 0.032 | 1.23 ± 0.14 | 0.046 ± 0.005 | 1.00 ± 0.14 | 0.037 ± 0.005 |
| Red marrow | 1.16 | 0.043 | 2.02 ± 0.18 | 0.075 ± 0.007 | 1.54 ± 0.11 | 0.057 ± 0.004 |
| Testes | 0.76 | 0.028 | — | — | 1.05 ± 0.11 | 0.039 ± 0.004 |
| Ovaries | 1.05 | 0.039 | 1.80 ± 0.15 | 0.067 ± 0.006 | — | — |
| Bladder wall | 1.32 | 0.049 | 9.66 ± 8.63 | 0.358 ± 0.319 | 3.32 ± 2.02 | 0.123 ± 0.075 |
| Effective dose equivalent | 2.97 | 0.110 | 3.69 ± 0.59 | 0.137 ± 0.022 | 2.73 ± 0.73 | 0.101 ± 0.020 |