Competitive Inhibition of Accumulation of 99mTc-NC100586 in Human Colon Tumors by STa (5–18) in CD-1 Nude Mice
| Site | 99mTc-NC100586 | 99mTc-NC100586 + 100 μg STa (5–18) |
|---|---|---|
| %ID/g | ||
| Tumor | 1.36 ± 0.22 | 0.36 ± 0.07; P < 0.05 |
| Liver | 0.40 ± 0.10 | 0.23 ± 0.04; NS |
| Muscle | 0.10 ± 0.02 | 0.14 ± 0.11; NS |
| Relative retention | ||
| Tumor | 2.35 ± 0.56 | 0.88 ± 0.25; P < 0.05 |
| Liver | 0.69 ± 0.13 | 0.56 ± 0.06; NS |
| Muscle | 0.15 ± 0.02 | 0.32 ± 0.23; NS |
NS = not statistically significant.
Data collected 120 min after injection in subcutaneous tumor model represent mean ± SD of at least 6 replicate animals. P was calculated using Student t test.