Biodistribution of 99mTc-NC100586 and 99mTc-NC100588 in CD-1 Nude Mice
| Site | 5 min | 60 min | 120 min | 240 min |
|---|---|---|---|---|
| 99mTc-NC100586 | ||||
| Blood (%ID/g) | 10.6 ± 0.4 | 0.8 ± 0.0 | 0.1 ± 0.1 | 0.1 ± 0.1 |
| Muscle (%ID/g) | 2.3 ± 0.4 | 0.2 ± 0.0 | 0.1 ± 0.1 | 0.1 ± 0.0 |
| Liver (%ID) | 4.3 ± 0.3 | 1.4 ± 0.1 | 0.5 ± 0.2 | 0.2 ± 0.1 |
| Kidney (%ID) | 11.1 ± 1.6 | 8.5 ± 2.4 | 3.6 ± 1.3 | 1.7 ± 0.2 |
| Urine (%ID) | 0.3 ± 0.1 | 74.0 ± 2.4 | 79.0 ± 9.0 | 89.0 ± 7.3 |
| Gastrointestinal tract (%ID) | 4.1 ± 0.5 | 3.9 ± 0.9 | 14.4 ± 2.0 | Not determined |
| 99mTc-NC100588 | ||||
| Blood (%ID/g) | 8.3 ± 2.4 | 0.5 ± 0.2 | 0.2 ± 0.02 | 0.1 ± 0.0 |
| Muscle (%ID/g) | 2.0 ± 0.9 | 0.7 ± 0.5 | 0.5 ± 0.8 | 0.1 ± 0.1 |
| Liver (%ID) | 9.7 ± 0.4 | 16.2 ± 2.3 | 13.4 ± 2.3 | 2.6 ± 0.7 |
| Kidney (%ID) | 16.8 ± 0.5 | 35.8 ± 2.0 | 18.7 ± 4.9 | 1.7 ± 0.3 |
| Urine (%ID) | 1.0 ± 0.8 | 35.4 ± 7.0 | 32.0 ± 9.0 | 54.2 ± 17.0 |
| Gastrointestinal tract (%ID) | 3.5 ± 1.6 | 19.6 ± 2.6 | 12.6 ± 3.0 | 29.6 ± 3.0 |
Values are mean ± SD of 3 CD-1 mice (without tumors) per time point.