Results for Measurement of Hippuran Clearance and RBF
| Subject no. | Group | RBF1 (mL/min/cm3) | RBF2 (mL/min/cm3) | HIPP1 (mL/min) | HIPP2 (mL/min) |
|---|---|---|---|---|---|
| 1 | N | 2.89 | 2.29 | 871 | 434 |
| 2 | N | 3.66 | 4.47 | 818 | 569 |
| 3 | N | 3.04 | 3.17 | 797 | 554 |
| 4 | N | 2.77 | 4.12 | 628 | 409 |
| 5 | N | 3.82 | 2.92 | 643 | 488 |
| 6 | M | 1.27 | 0.51 | 171 | —* |
| 7 | M | 1.94 | 1.97 | 264 | 252 |
| 8 | M | 2.11 | 1.83 | 356 | 362 |
| 9 | M | 2.30 | 2.52 | 220 | 244 |
| 10 | M | 3.86 | 3.09 | 282 | 250 |
| 11 | M | 1.90 | 2.04 | 372 | 337 |
| 12 | S | 1.06 | 0.91 | 147 | 107 |
| 13 | S | 4.11 | 3.18 | 162 | 165 |
| 14 | S | 1.01 | 0.53 | 181 | 160 |
| 15 | S | 1.18 | 0.99 | 317 | 280 |
RBF1 and RBF2 = RBF measured before treatment and 7 d after treatment with probenecid, respectively; HIPP1 and HIPP2 = first and second hippuran clearance rate measurement, respectively; N = normal (healthy) subject; M = moderate renal disease; S = severe renal disease.
↵* — indicates no study was done.