Receptor Concentration Estimated Using Kinetics and Graphic Approaches on Data Obtained from the 8 Multiinjection Experiments
| Parameter | Multiinjection method | Graphic method | ||
|---|---|---|---|---|
| First estimation type | Second estimation type | Third estimation type | ||
| Vascular fraction | ||||
| FV value | Estimated | 0.4 | 0.4 | 0.4 |
| Function used | Blood sampling | Blood sampling | Blood sampling | PET measurement in cavity |
| Input function/corrections | ||||
| Protein binding | 22% | — | — | — |
| μ (red cells) | — | — | 1.15 | 1.15 |
| Function used | Plasma sampling | Plasma sampling | Blood sampling | PET measurement in cavity |
| Receptor concentration | ||||
| Experiment 1 | 17.5 | 15.8 | 15.7 | 16.0 |
| Experiment 2 | 11.6 | 11.2 | 10.9 | 10.7 |
| Experiment 3 | 11.5 | 11.6 | 11.5 | 11.5 |
| Experiment 4 | 8.8 | 9.6 | 9.6 | 9.7 |
| Experiment 5 | 17.4 | 17.4 | 18.2 | 17.6 |
| Experiment 6 | 12.1 | 15.4 | 14.1 | 12.9 |
| Experiment 7 | 10.0 | 13.2 | 11.5 | 12.3 |
| Experiment 8 | 12.9 | 15.2 | 14.1 | 14.5 |
| Mean | 12.7 | 13.7 | 13.2 | 13.1 |
| SD | 3.2 | 2.7 | 2.8 | 2.7 |
Table 1 shows doses used. Receptor concentration is in pmol/mL. Detailed results of multiinjection approach are given in Table 2.