Differences Between LEA and LEC Rats
| Parameter | LEA rats (mean ± SD) | LEC rats (mean ± SD) | P |
|---|---|---|---|
| Serum albumin (g/dL) | 4.1 ± 0.6 | 4.2 ± 0.4 | 0.6 |
| Serum bilirubin (mg/dL) | 0.8 ± 0.4 | 0.9 ± 0.3 | 0.6 |
| Serum ALT (IU/L) | 64 ± 35 | 261 ± 211 | 0.01 |
| Serum ceruloplasmin (mg/dL) | 33 ± 4 | Undetectable | — |
| Hepatic ATP7B mRNA | Present | Absent | — |
| Biliary copper (micrograms of copper excreted during final 40 min of 1-h collection after intrasplenic copper) | 7,279 ± 751 | 603 ± 519 | 0.009 |
| Hepatic copper content (μg/g of dry weight) | 12.6 ± 1.4 | 840 ± 294 | 0.016 |
Data analysis used Student t test.