Biodistribution of Lipophilic Cations in Mice
| Site | 5 min after administration | 120 min after administration | ||
|---|---|---|---|---|
| 3H-TPP | 99mTc-MIBI | 3H-TPP | 99mTc-MIBI | |
| Blood | 0.13 ± 0.02 | 0.41 ± 0.04 | 0.09 ± 0.02 | 0.26 ± 0.05 |
| Brain | 0.09 ± 0.04 | 0.08 ± 0.03 | 0.06 ± 0.02 | 0.08 ± 0.04 |
| Heart | 24.50 ± 4.72 | 9.07 ± 1.26 | 20.70 ± 1.92 | 5.08 ± 0.25 |
| Lung | 5.41 ± 0.35 | 2.11 ± 0.51 | 2.81 ± 0.41 | 0.98 ± 0.19 |
| Liver | 9.09 ± 0.53 | 6.85 ± 1.18 | 6.12 ± 1.08 | 5.55 ± 1.08 |
| Spleen | 3.30 ± 0.25 | 1.84 ± 0.41 | 1.93 ± 0.47 | 1.27 ± 0.33 |
| Kidney | 6.11 ± 0.44 | 27.90 ± 3.77 | 4.37 ± 0.66 | 12.60 ± 2.57 |
| Muscle | 3.05 ± 0.72 | 2.44 ± 0.23 | 2.22 ± 0.41 | 1.56 ± 0.31 |
Data are mean (±SD) %ID/g.